You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence
|
|---|---|
| Published in |
Nature Communications, August 2018
|
| DOI | 10.1038/s41467-018-05893-z |
| Pubmed ID | |
| Authors |
G. Costa, M. Gildenhard, M. Eldering, R. L. Lindquist, A. E. Hauser, R. Sauerwein, C. Goosmann, V. Brinkmann, P. Carrillo-Bustamante, E. A. Levashina |
| Abstract |
Malaria is a fatal human parasitic disease transmitted by a mosquito vector. Although the evolution of within-host malaria virulence has been the focus of many theoretical and empirical studies, the vector's contribution to this process is not well understood. Here, we explore how within-vector resource exploitation would impact the evolution of within-host Plasmodium virulence. By combining within-vector dynamics and malaria epidemiology, we develop a mathematical model, which predicts that non-competitive parasitic resource exploitation within-vector restricts within-host parasite virulence. To validate our model, we experimentally manipulate mosquito lipid trafficking and gauge within-vector parasite development and within-host infectivity and virulence. We find that mosquito-derived lipids determine within-host parasite virulence by shaping development (quantity) and metabolic activity (quality) of transmissible sporozoites. Our findings uncover the potential impact of within-vector environment and vector control strategies on the evolution of malaria virulence. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 20% |
| United States | 3 | 12% |
| Portugal | 1 | 4% |
| Kenya | 1 | 4% |
| Spain | 1 | 4% |
| Germany | 1 | 4% |
| Puerto Rico | 1 | 4% |
| Australia | 1 | 4% |
| Unknown | 11 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 44% |
| Scientists | 8 | 32% |
| Practitioners (doctors, other healthcare professionals) | 4 | 16% |
| Science communicators (journalists, bloggers, editors) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 23% |
| Researcher | 15 | 16% |
| Student > Master | 10 | 11% |
| Student > Bachelor | 8 | 9% |
| Student > Postgraduate | 6 | 6% |
| Other | 9 | 10% |
| Unknown | 24 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 27% |
| Biochemistry, Genetics and Molecular Biology | 20 | 21% |
| Immunology and Microbiology | 10 | 11% |
| Environmental Science | 3 | 3% |
| Medicine and Dentistry | 3 | 3% |
| Other | 7 | 7% |
| Unknown | 26 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2019.
All research outputs
#2,538,504
of 25,307,660 outputs
Outputs from Nature Communications
#29,307
of 56,087 outputs
Outputs of similar age
#49,833
of 341,323 outputs
Outputs of similar age from Nature Communications
#782
of 1,435 outputs
Altmetric has tracked 25,307,660 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,087 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,323 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 1,435 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.