Title |
Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased gut permeability the missing link?
|
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Published in |
Journal of Translational Medicine, August 2018
|
DOI | 10.1186/s12967-018-1622-4 |
Pubmed ID | |
Authors |
Seah H. Lim, Barbara A. Methé, Bettina M. Knoll, Alison Morris, Stephen K. Obaro |
Abstract |
Non-typhoidal Salmonella usually induces self-limiting gastroenteritis. However, in many parts of Africa, especially in individuals who are malnourished, infected with malaria, or have sickle cell disease, the organism causes serious and potentially fatal systemic infections. Since the portal of entry of non-typhoidal Salmonella into the systemic circulation is by way of the intestine, we argue that an increased gut permeability plays a vital role in the initiation of invasive non-typhoidal Salmonella in these patients. Here, we will appraise the evidence supporting a breach in the intestinal barrier and propose the mechanisms for the increased risks for invasive non-typhoidal Salmonella infections in these individuals. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 19% |
Student > Ph. D. Student | 7 | 12% |
Student > Bachelor | 5 | 9% |
Student > Postgraduate | 4 | 7% |
Researcher | 4 | 7% |
Other | 10 | 17% |
Unknown | 17 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 10 | 17% |
Biochemistry, Genetics and Molecular Biology | 10 | 17% |
Medicine and Dentistry | 6 | 10% |
Agricultural and Biological Sciences | 6 | 10% |
Nursing and Health Professions | 2 | 3% |
Other | 5 | 9% |
Unknown | 19 | 33% |