Title |
Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases
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Published in |
Immunity & Ageing, November 2015
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DOI | 10.1186/s12979-015-0046-8 |
Pubmed ID | |
Authors |
Sandro Dattilo, Cesare Mancuso, Guido Koverech, Paola Di Mauro, Maria Laura Ontario, Cateno Concetto Petralia, Antonino Petralia, Luigi Maiolino, Agostino Serra, Edward J. Calabrese, Vittorio Calabrese |
Abstract |
Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, provide more comprehensive overview of the interaction of proteins, as well as the interplay among processes involved in neuroprotection. Here by introducing the hormetic dose response concept, the mechanistic foundations and applications to the field of neuroprotection, we discuss the emerging role of heat shock protein as prominent member of vitagene network in neuroprotection and redox proteomics as a tool for investigating redox modulation of stress responsive vitagenes. Hormetic mechanisms are reviewed as possibility of targeted therapeutic manipulation in a cell-, tissue- and/or pathway-specific manner at appropriate points in the neurodegenerative disease process. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 90 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 16% |
Student > Ph. D. Student | 13 | 14% |
Researcher | 12 | 13% |
Student > Master | 10 | 11% |
Student > Doctoral Student | 7 | 8% |
Other | 17 | 19% |
Unknown | 17 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 17% |
Medicine and Dentistry | 12 | 13% |
Biochemistry, Genetics and Molecular Biology | 9 | 10% |
Neuroscience | 7 | 8% |
Chemistry | 5 | 6% |
Other | 20 | 22% |
Unknown | 22 | 24% |