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EFFECTIVENESS OF IMMUNONUTRITION ON INFLAMMATORY MARKERS IN PATIENTS WITH CANCER; RANDOMIZED CLINICAL TRIAL.

Overview of attention for article published in Nutrición Hospitalaria, October 2015
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Title
EFFECTIVENESS OF IMMUNONUTRITION ON INFLAMMATORY MARKERS IN PATIENTS WITH CANCER; RANDOMIZED CLINICAL TRIAL.
Published in
Nutrición Hospitalaria, October 2015
DOI 10.3305/nh.2015.32.4.9507
Pubmed ID
Authors

Elizabeth Pérez Cruz, Arturo Reyes Marín, Juan Asbun Bojalil, Jose Ignacio Arteaga Morfin

Abstract

malnutrition is a common complication in patients with cancer and is associated with immunosuppression and alterations with inflammatory response. the aim of our study was to evaluate the effect of enteral nutrition supplemented with two enteral formulas on inflammatory markers (CRP, IL-6 and FNT) in cancer patients undergoing chemotherapy. randomized control trial, conducted at the Hospital Juarez of Mexico in patients with cancer undergoing chemotherapy with IRN < 97.5 and SGA B/C. Patients were randomly allocated to two groups: group I (immunomodulatory), group II (high 3). The intervention began on the first day of chemotherapy until day 10 after. We evaluated nutritional status and an inflammatory marker on days 0, +5, +10 QT. Statistical analysis was performed with T Student, x2 and analysis of variance for repeated measurements. P < 0.05 was considered statistically significant. a total of 29 patients were analyzed, 27 (62.8%) females and 16 (37.2%) males. Mean age 43.91 + 11.3 years old. Malnutrition prevalence was 48.8% moderate and 51.2% severe. Prealbumin levels significantly increase in group II vs group I (p < 0.05). Both groups maintenance body weight, lean mass and fat mass. No decrease levels of CRP, IL-6 and FNT. enteral supplementation during chemotherapy inhibits nutritional deterioration and maintenance body weight and lean mass. No decreased levels of inflammatory markers.

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Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 17 29%
Student > Master 9 15%
Other 5 8%
Researcher 4 7%
Lecturer 3 5%
Other 6 10%
Unknown 15 25%
Readers by discipline Count As %
Medicine and Dentistry 20 34%
Nursing and Health Professions 7 12%
Psychology 6 10%
Sports and Recreations 3 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 5 8%
Unknown 16 27%