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In vitro antioxidant and cholinesterase inhibitory activities of methanolic fruit extract of Phyllanthus acidus

Overview of attention for article published in BMC Complementary and Alternative Medicine, November 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
1 news outlet

Citations

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18 Dimensions

Readers on

mendeley
47 Mendeley
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Title
In vitro antioxidant and cholinesterase inhibitory activities of methanolic fruit extract of Phyllanthus acidus
Published in
BMC Complementary and Alternative Medicine, November 2015
DOI 10.1186/s12906-015-0930-y
Pubmed ID
Authors

Md. Moniruzzaman, Md. Asaduzzaman, Md. Sarwar Hossain, Jyotirmoy Sarker, S. M. Abdur Rahman, Mamunur Rashid, Md. Mosiqur Rahman

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by loss of memory and cognition. Cholinergic deficit and oxidative stress have been implicated in the pathogenesis of AD. Therefore, inhibition of acetylcholinesterase and oxidation are the two promising strategies in the development of drug for AD. Phyllanthus acidus, belonging to the family Euphorbiaceae, is a tree and has been used in traditional medicine to treat several pain, inflammatory and oxidative stress related disorders such as rheumatism, bronchitis, asthma, respiratory disorder, also important to promote intellect and enhance memory, thus supporting its possible anti-Alzheimer's properties. In this study, P. acidus was evaluated for its cholinesterase inhibitory and antioxidant activities. In this study, we evaluated the antioxidant potential and neuroprotective activity of P. acidus by assessing total phenol content (FCR assay), total flavonoid content, total antioxidant capacity, Fe (3+) reducing power capacity, DPPH (2, 2-diphenyl-1-picrylhydrazyl) and hydroxyl radical scavenging capacity, lipid peroxidation inhibition activity & metal chelating activity. In addition acetylcholinestrase (AChE) and butyrylcholinestrase (BChE) inhibitory activities were performed using Ellman's method. Total phenolic content and total flavonoid content of the extract were 116.98 mg of gallic acid equivalent and 168.24 mg of quercetin equivalent per gm of dried extract. The methanolic extract of P. acidus (MEPA) showed considerable total antioxidant activity and reducing capacity. In DPPH scavenging assay and hydroxyl radical scavenging assay, the MEPA showed 84.33 % and 77.21 % scavenging having IC50 of 15.62 and 59.74 μg/ml respectively. In lipid peroxidation inhibition activity MEPA showed moderate inhibition of peroxidation at all concentrations with IC50 value of 471.63 μg/ml and exhibited metal chelating activity with IC50 value 308.67 μg/ml. The MEPA exhibited inhibition of rat brain acetylcholinesterase and human blood butyrylcholinesterase in a dose dependent manner and the IC50 value was found to be 1009.87 μg/ml and 449.51 μg/ml respectively. These results of the present study reveal that MEPA has considerable amount of antioxidant activity as well as anti-acetylcholinesterase and anti-butyrylcholinesterase activity which suggest its effectiveness against Alzheimer's disease and other neurodegenerative disorders.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 45 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 30%
Student > Ph. D. Student 8 17%
Student > Postgraduate 5 11%
Student > Bachelor 4 9%
Librarian 2 4%
Other 8 17%
Unknown 6 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 17%
Psychology 8 17%
Pharmacology, Toxicology and Pharmaceutical Science 5 11%
Biochemistry, Genetics and Molecular Biology 5 11%
Medicine and Dentistry 4 9%
Other 8 17%
Unknown 9 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2015.
All research outputs
#875,425
of 6,564,711 outputs
Outputs from BMC Complementary and Alternative Medicine
#295
of 1,734 outputs
Outputs of similar age
#40,607
of 208,284 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#6
of 78 outputs
Altmetric has tracked 6,564,711 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,734 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.