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Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions

Overview of attention for article published in Journal of Endodontics, October 2015
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Title
Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions
Published in
Journal of Endodontics, October 2015
DOI 10.1016/j.joen.2015.08.027
Pubmed ID
Authors

Aleksandar Jakovljevic, Miroslav Andric, Aleksandra Knezevic, Ivan Soldatovic, Nadja Nikolic, Danijela Karalic, Jelena Milasin

Abstract

Different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) possess specific pathogenic abilities because of various interactions with the host's immune system and differences in cell tropism. The aim of this study was to determine the distribution of HCMV and EBV genotypes in apical periodontitis lesions in relation to their clinical and histopathologic features. One hundred samples of apical periodontitis lesions and 25 control samples (healthy pulp tissue) were collected. The presence of HCMV glycoprotein B (gB) and EBV nuclear antigen-2 genotypes was analyzed by nested polymerase chain reaction and restriction fragment length polymorphisms analysis. EBV and HCMV were detected in apical periodontitis lesions at significantly higher frequencies than in healthy pulp controls (P = .020 and P = .020, respectively). HCMV gB type II was significantly more frequent compared with gB type I in the examined groups (P = .036). No HCMV gB type III or IV products were found. In both periapical lesions and controls, EBV-1 occurred more often compared with EBV-2 (P = .001). Dual EBV and HCMV coinfection was more frequently detected in large-size periapical lesions (P = .038). Both HCMV and EBV are associated with inflammatory processes of periapical bone destruction. HCMV gB type II and EBV-1 are the most prevalent genotypes in apical periodontitis lesions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 21%
Student > Postgraduate 10 18%
Other 4 7%
Student > Doctoral Student 4 7%
Student > Ph. D. Student 4 7%
Other 12 21%
Unknown 11 19%
Readers by discipline Count As %
Medicine and Dentistry 28 49%
Biochemistry, Genetics and Molecular Biology 4 7%
Immunology and Microbiology 4 7%
Engineering 2 4%
Agricultural and Biological Sciences 1 2%
Other 2 4%
Unknown 16 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#20,653,708
of 25,368,786 outputs
Outputs from Journal of Endodontics
#1,512
of 2,291 outputs
Outputs of similar age
#210,424
of 287,355 outputs
Outputs of similar age from Journal of Endodontics
#18
of 43 outputs
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