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Role of surface charge in determining the biological effects of CdSe/ZnS quantum dots

Overview of attention for article published in International Journal of Nanomedicine, November 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Title
Role of surface charge in determining the biological effects of CdSe/ZnS quantum dots
Published in
International Journal of Nanomedicine, November 2015
DOI 10.2147/ijn.s94543
Pubmed ID
Authors

Qiangqiang Liu, Hongxia Li, Qiyue Xia, Ying Liu, Kai Xiao

Abstract

The growing potential of quantum dots (QDs) in biomedical applications has provoked the urgent need to thoroughly address their interaction with biological systems. However, only limited studies have been performed to explore the effects of surface charge on the biological behaviors of QDs. In the present study, three commercially available QDs with different surface coatings were used to systematically evaluate the effects of surface charge on the cellular uptake, cytotoxicity, and in vivo biodistribution of QDs. Our results demonstrated that charged QDs entered both cancer cells and macrophages more efficiently than neutral ones, while negative QDs internalized mostly. Upon entry into cells, QDs were localized in different subcellular compartments (eg, cytoplasm and lysosomes) depending on the surface charge. Interestingly, inconsistent with the result of internalization, positive QDs but not negative QDs exhibited severe cytotoxicity, which was likely due to their disruption of cell membrane integrity, and production of reactive oxygen species. Biodistribution studies demonstrated that negative and neutral QDs preferentially distributed in the liver and the spleen, whereas positive QDs mainly deposited in the kidney with obvious uptake in the brain. In general, surface charge plays crucial roles in determining the biological interactions of QDs.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 43%
Student > Bachelor 4 9%
Student > Doctoral Student 2 5%
Lecturer 2 5%
Student > Postgraduate 2 5%
Other 5 11%
Unknown 10 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 16%
Chemistry 6 14%
Materials Science 4 9%
Engineering 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 9 20%
Unknown 13 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#15,043,267
of 25,576,275 outputs
Outputs from International Journal of Nanomedicine
#1,606
of 4,142 outputs
Outputs of similar age
#141,080
of 295,307 outputs
Outputs of similar age from International Journal of Nanomedicine
#39
of 112 outputs
Altmetric has tracked 25,576,275 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,142 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,307 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.