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Benzothiazole carbamates and amides as antiproliferative species

Overview of attention for article published in European Journal of Medicinal Chemistry, September 2018
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Citations

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Title
Benzothiazole carbamates and amides as antiproliferative species
Published in
European Journal of Medicinal Chemistry, September 2018
DOI 10.1016/j.ejmech.2018.08.067
Pubmed ID
Authors

Milica Videnović, Marija Mojsin, Milena Stevanović, Igor Opsenica, Tatjana Srdić-Rajić, Bogdan Šolaja

Abstract

A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, submicromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 1 14%
Other 1 14%
Student > Bachelor 1 14%
Student > Ph. D. Student 1 14%
Researcher 1 14%
Other 1 14%
Unknown 1 14%
Readers by discipline Count As %
Chemistry 2 29%
Pharmacology, Toxicology and Pharmaceutical Science 1 14%
Business, Management and Accounting 1 14%
Unspecified 1 14%
Unknown 2 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2018.
All research outputs
#11,945,285
of 13,472,025 outputs
Outputs from European Journal of Medicinal Chemistry
#2,820
of 3,443 outputs
Outputs of similar age
#228,503
of 265,067 outputs
Outputs of similar age from European Journal of Medicinal Chemistry
#59
of 89 outputs
Altmetric has tracked 13,472,025 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,443 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,067 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.