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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects
|
|---|---|
| Published in |
Nature Neuroscience, November 2015
|
| DOI | 10.1038/nn.4169 |
| Pubmed ID | |
| Authors |
Dennis Mircsof, Maéva Langouët, Marlène Rio, Sébastien Moutton, Karine Siquier-Pernet, Christine Bole-Feysot, Nicolas Cagnard, Patrick Nitschke, Ludmila Gaspar, Matej Žnidarič, Olivier Alibeu, Ann-Kristina Fritz, David P Wolfer, Aileen Schröter, Giovanna Bosshard, Markus Rudin, Christina Koester, Florence Crestani, Petra Seebeck, Nathalie Boddaert, Katrina Prescott, Rochelle Hines, Steven J Moss, Jean-Marc Fritschy, Arnold Munnich, Jeanne Amiel, Steven A Brown, Shiva K Tyagarajan, Laurence Colleaux |
| Abstract |
The NONO protein has been characterized as an important transcriptional regulator in diverse cellular contexts. Here we show that loss of NONO function is a likely cause of human intellectual disability and that NONO-deficient mice have cognitive and affective deficits. Correspondingly, we find specific defects at inhibitory synapses, where NONO regulates synaptic transcription and gephyrin scaffold structure. Our data identify NONO as a possible neurodevelopmental disease gene and highlight the key role of the DBHS protein family in functional organization of GABAergic synapses. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 20% |
| United States | 1 | 20% |
| Spain | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Austria | 1 | <1% |
| Slovenia | 1 | <1% |
| Unknown | 134 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 21% |
| Researcher | 17 | 12% |
| Student > Master | 17 | 12% |
| Student > Doctoral Student | 11 | 8% |
| Student > Bachelor | 9 | 7% |
| Other | 25 | 18% |
| Unknown | 30 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 20% |
| Neuroscience | 25 | 18% |
| Biochemistry, Genetics and Molecular Biology | 23 | 17% |
| Medicine and Dentistry | 11 | 8% |
| Nursing and Health Professions | 5 | 4% |
| Other | 17 | 12% |
| Unknown | 29 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2016.
All research outputs
#4,786,774
of 23,509,253 outputs
Outputs from Nature Neuroscience
#3,312
of 5,317 outputs
Outputs of similar age
#57,502
of 253,752 outputs
Outputs of similar age from Nature Neuroscience
#78
of 87 outputs
Altmetric has tracked 23,509,253 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,317 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 54.2. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,752 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.