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Influence of obesity on vertebral fracture prevalence and vitamin D status in postmenopausal women

Overview of attention for article published in Nutrition & Metabolism, November 2015
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Title
Influence of obesity on vertebral fracture prevalence and vitamin D status in postmenopausal women
Published in
Nutrition & Metabolism, November 2015
DOI 10.1186/s12986-015-0041-2
Pubmed ID
Authors

A. El Maghraoui, S. Sadni, A. El Maataoui, A. Majjad, A. Rezqi, Z. Ouzzif, A. Mounach

Abstract

It is well established that weight is an important determinant of bone health. Whereas obesity is associated with increased mortality and morbidity from diabetes and cardiovascular diseases, high body weight is widely believed to be associated to hypovitaminosis D and protective against the development of osteoporosis and fracture risk. The objective of the study was to evaluate the effect of BMI on vitamin D status and on densitometric vertebral fractures (VFs) in a large series of asymptomatic women aged over 50 who had a VFA examination during their bone mineral density (BMD) testing. We enrolled 429 postmenopausal women (mean age, weight and BMI of 59.5 ± 8.3 (50 to 83) years, 75.8 ± 13.3 (35 to 165) kgs and 29.9 ± 5.2 (14.6 to 50.8) kg/m(2), respectively. Lateral VFA images and scans of the lumbar spine and proximal femur were obtained using a Lunar Prodigy densitometer. VFs were defined using the Genant semiquantitative (SQ) approach. Clinical risk factors of osteoporosis were collected and 25-hydroxivitamin D was measured using electrochimiluminescence (Roche). Prevalence of osteoporosis and hypovitaminosis D (<20 ng/ml) was 21.0 % and 78.1 % respectively. VFs grade 2/3were identified in 76 (17.7 %). Comparison between women according to their BMI showed that obese women had a higher BMD and less proportion of women with osteoporosis and VFs grade 2/3 than lean and overweight women. The prevalence of VFs globally increased with age and as BMI and BMD declined. Stepwise regression analysis showed that the presence of osteoporosis was independently related to BMI and history of fractures while the presence of grade 2/3 VFs was independently related to age, hypovitaminosis D and years of menopause. Obese women had a higher BMD and lower prevalence of VFs. VFs were significantly related to age, hypovitaminosis D and years since menopause. However, among obese women, prevalence of VFs was increased in osteoporotic women.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Morocco 1 1%
Unknown 66 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 19%
Student > Bachelor 11 16%
Other 5 7%
Researcher 5 7%
Student > Ph. D. Student 5 7%
Other 13 19%
Unknown 15 22%
Readers by discipline Count As %
Medicine and Dentistry 23 34%
Nursing and Health Professions 9 13%
Biochemistry, Genetics and Molecular Biology 5 7%
Agricultural and Biological Sciences 3 4%
Sports and Recreations 2 3%
Other 5 7%
Unknown 20 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2015.
All research outputs
#15,350,522
of 22,833,393 outputs
Outputs from Nutrition & Metabolism
#673
of 949 outputs
Outputs of similar age
#164,231
of 281,503 outputs
Outputs of similar age from Nutrition & Metabolism
#20
of 25 outputs
Altmetric has tracked 22,833,393 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 949 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.5. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,503 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.