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Quantitative analysis of iris parameters in keratoconus patients using optical coherence tomography

Overview of attention for article published in Arquivos Brasileiros de Oftalmologia, January 2015
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Title
Quantitative analysis of iris parameters in keratoconus patients using optical coherence tomography
Published in
Arquivos Brasileiros de Oftalmologia, January 2015
DOI 10.5935/0004-2749.20150080
Pubmed ID
Authors

Gustavo Bonfadini, Karun Arora, Lucas M. Vianna, Mauro Campos, David Friedman, Beatriz Muñoz, Albert S Jun

Abstract

To investigate the relationship between quantitative iris parameters and the presence of keratoconus. Cross-sectional observational study that included 15 affected eyes of 15 patients with keratoconus and 26 eyes of 26 normal age- and sex-matched controls. Iris parameters (area, thickness, and pupil diameter) of affected and unaffected eyes were measured under standardized light and dark conditions using anterior segment optical coherence tomography (AS-OCT). To identify optimal iris thickness cutoff points to maximize the sensitivity and specificity when discriminating keratoconus eyes from normal eyes, the analysis included the use of receiver operating characteristic (ROC) curves. Iris thickness and area were lower in keratoconus eyes than in normal eyes. The mean thickness at the pupillary margin under both light and dark conditions was found to be the best parameter for discriminating normal patients from keratoconus patients. Diagnostic performance was assessed by the area under the ROC curve (AROC), which had a value of 0.8256 with 80.0% sensitivity and 84.6% specificity, using a cutoff of 0.4125 mm. The sensitivity increased to 86.7% when a cutoff of 0.4700 mm was used. In our sample, iris thickness was lower in keratoconus eyes than in normal eyes. These results suggest that tomographic parameters may provide novel adjunct approaches for keratoconus screening.

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 18%
Student > Master 3 18%
Student > Bachelor 1 6%
Other 1 6%
Student > Doctoral Student 1 6%
Other 1 6%
Unknown 7 41%
Readers by discipline Count As %
Medicine and Dentistry 4 24%
Biochemistry, Genetics and Molecular Biology 1 6%
Business, Management and Accounting 1 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Social Sciences 1 6%
Other 3 18%
Unknown 6 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2015.
All research outputs
#11,089,697
of 12,471,795 outputs
Outputs from Arquivos Brasileiros de Oftalmologia
#138
of 166 outputs
Outputs of similar age
#276,977
of 339,229 outputs
Outputs of similar age from Arquivos Brasileiros de Oftalmologia
#17
of 30 outputs
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