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Use of tramadol in early pregnancy and congenital malformation risk

Overview of attention for article published in Reproductive Toxicology, October 2015
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Title
Use of tramadol in early pregnancy and congenital malformation risk
Published in
Reproductive Toxicology, October 2015
DOI 10.1016/j.reprotox.2015.10.007
Pubmed ID
Authors

Bengt Källén, Margareta Reis

Abstract

Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1 682 846 women (1 797 678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 17%
Student > Master 7 10%
Other 7 10%
Researcher 4 6%
Student > Ph. D. Student 4 6%
Other 13 18%
Unknown 25 35%
Readers by discipline Count As %
Medicine and Dentistry 21 29%
Pharmacology, Toxicology and Pharmaceutical Science 9 13%
Nursing and Health Professions 4 6%
Unspecified 3 4%
Computer Science 2 3%
Other 8 11%
Unknown 25 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2016.
All research outputs
#20,653,708
of 25,371,288 outputs
Outputs from Reproductive Toxicology
#1,383
of 1,684 outputs
Outputs of similar age
#216,085
of 294,821 outputs
Outputs of similar age from Reproductive Toxicology
#15
of 20 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,684 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,821 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.