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A threading receptor for polysaccharides

Overview of attention for article published in Nature Chemistry, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

24 tweeters


28 Dimensions

Readers on

46 Mendeley
A threading receptor for polysaccharides
Published in
Nature Chemistry, January 2016
DOI 10.1038/nchem.2395
Pubmed ID

Tiddo J. Mooibroek, Juan M. Casas-Solvas, Robert L. Harniman, Charles M. Renney, Tom S. Carter, Matthew P. Crump, Anthony P. Davis


Cellulose, chitin and related polysaccharides are key renewable sources of organic molecules and materials. However, poor solubility tends to hamper their exploitation. Synthetic receptors could aid dissolution provided they are capable of cooperative action, for example by multiple threading on a single polysaccharide molecule. Here we report a synthetic receptor designed to form threaded complexes (polypseudorotaxanes) with these natural polymers. The receptor binds fragments of the polysaccharides in aqueous solution with high affinities (Ka up to 19,000 M(-1)), and is shown-by nuclear Overhauser effect spectroscopy-to adopt the threading geometry. Evidence from induced circular dichroism and atomic force microscopy implies that the receptor also forms polypseudorotaxanes with cellulose and its polycationic analogue chitosan. The results hold promise for polysaccharide solubilization under mild conditions, as well as for new approaches to the design of biologically active molecules.

Twitter Demographics

The data shown below were collected from the profiles of 24 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Netherlands 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 28%
Student > Master 9 20%
Researcher 8 17%
Unspecified 4 9%
Student > Bachelor 4 9%
Other 8 17%
Readers by discipline Count As %
Chemistry 35 76%
Unspecified 4 9%
Biochemistry, Genetics and Molecular Biology 2 4%
Agricultural and Biological Sciences 2 4%
Chemical Engineering 1 2%
Other 2 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
of 12,154,410 outputs
Outputs from Nature Chemistry
of 2,049 outputs
Outputs of similar age
of 313,514 outputs
Outputs of similar age from Nature Chemistry
of 66 outputs
Altmetric has tracked 12,154,410 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,049 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,514 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.