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Association between environmental exposures and granulomatosis with polyangiitis in Canterbury, New Zealand

Overview of attention for article published in Arthritis Research & Therapy, November 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
3 tweeters

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
38 Mendeley
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Title
Association between environmental exposures and granulomatosis with polyangiitis in Canterbury, New Zealand
Published in
Arthritis Research & Therapy, November 2015
DOI 10.1186/s13075-015-0852-6
Pubmed ID
Authors

Lisa K. Stamp, Peter T. Chapman, Janine Francis, Lutz Beckert, Christopher Frampton, Richard A. Watts, John L. O’Donnell

Abstract

Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis. While aetiology is unknown the prominent respiratory involvement suggests inhaled antigens may be involved. The aim of this study was to identify environmental risk factors associated with GPA in Canterbury, New Zealand. A case-controlled study was undertaken. All GPA cases fulfilled American College of Rheumatology (ACR), Chapel Hill Consensus Criteria (CHCC) or the European Medicines Agency (EMA) criteria. Each case was gender matched with four controls - 2 musculoskeletal (osteoarthritis or fracture) and 2 respiratory (asthma or chronic obstructive pulmonary disease). One musculoskeletal control and one respiratory control were age matched with the case at the time of the interview (interview) and the remaining two controls were age matched at the time their case experienced the first symptom of vasculitis (index). A structured questionnaire to assess potential environmental agents was administered without blinding for case/control status. Data were analyzed using conditional logistic regression to allow for the individual matching of cases and controls to assess for association between environmental factors and GPA. 49 cases and 196 controls were recruited. 53 % were male and the mean ± standard deviation (SD) age of the cases was 64.9 ± 12.4 years, interview controls 65.1 ± 12.4.years and index controls 53.9 ± 14.5 years. Any reported exposure to dust (specifically silica and grain dust) was associated with GPA, odds ratio (OR) 3.6 (95 % confidence interval (CI); 1.5-8.3, p = 0.003). Occupation as a farm worker was associated with GPA OR 3.43 (1.5-7.5, p = 0.002). Specific gardening activities were associated with GPA including digging (OR 3.2; 1.4-7.0; p = 0.003), mowing (OR 2.7; 1.3-5.8; p = 0.008) and planting (OR 2.6; 1.2-5.5; p = 0.013). We have replicated findings from northern hemisphere studies identifying dust exposure as well as farm exposure as risk factors for the development of GPA. We have shown activities associated with exposure to inhaled antigens, in particular those related to farming or gardening activities may increase the risk of GPA.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 21%
Student > Master 6 16%
Other 4 11%
Student > Ph. D. Student 4 11%
Student > Doctoral Student 3 8%
Other 9 24%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 24 63%
Social Sciences 3 8%
Computer Science 2 5%
Psychology 1 3%
Immunology and Microbiology 1 3%
Other 2 5%
Unknown 5 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2018.
All research outputs
#825,678
of 12,451,992 outputs
Outputs from Arthritis Research & Therapy
#153
of 1,983 outputs
Outputs of similar age
#28,792
of 337,225 outputs
Outputs of similar age from Arthritis Research & Therapy
#26
of 293 outputs
Altmetric has tracked 12,451,992 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,225 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 293 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.