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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multiple Routes to Oncogenesis are Promoted by the Human Papillomavirus-Host Protein Network
|
|---|---|
| Published in |
Cancer Discovery, November 2018
|
| DOI | 10.1158/2159-8290.cd-17-1018 |
| Pubmed ID | |
| Authors |
Manon Eckhardt, Wei Zhang, Andrew M Gross, John Von Dollen, Jeffrey R Johnson, Kathleen E Franks-Skiba, Danielle L Swaney, Tasha L Johnson, Gwendolyn M Jang, Priya S Shah, Toni M Brand, Jacques Archambault, Jason F Kreisberg, Jennifer R Grandis, Trey Ideker, Nevan J Krogan |
| Abstract |
We have mapped a global network of virus-host protein interactions by purification of the complete set of Human Papillomavirus (HPV) proteins in multiple cell lines followed by mass spectrometry analysis. Integration of this map with tumor genome atlases shows that the virus targets human proteins frequently mutated in HPV(-) but not HPV(+) cancers, providing a unique opportunity to identify novel oncogenic events phenocopied by HPV infection. For example, we find that the Nrf2 transcriptional pathway, which protects against oxidative stress, is activated by interaction of the Nrf2 regulator Keap1 with the viral protein E1. We also demonstrate that the L2 HPV protein physically interacts with the RNF20/40 histone ubiquitination complex and promotes tumor cell invasion in an RNF20/40-dependent manner. This combined proteomic and genetic approach provides a systematic means to study the cellular mechanisms hijacked by virally induced cancers. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 33% |
| France | 2 | 7% |
| Spain | 2 | 7% |
| Israel | 1 | 4% |
| Canada | 1 | 4% |
| Unknown | 12 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 67% |
| Scientists | 5 | 19% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
| Unknown | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 115 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 31% |
| Researcher | 15 | 13% |
| Student > Master | 10 | 9% |
| Student > Bachelor | 10 | 9% |
| Student > Doctoral Student | 6 | 5% |
| Other | 21 | 18% |
| Unknown | 17 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 37% |
| Medicine and Dentistry | 12 | 10% |
| Agricultural and Biological Sciences | 10 | 9% |
| Immunology and Microbiology | 7 | 6% |
| Computer Science | 4 | 3% |
| Other | 15 | 13% |
| Unknown | 24 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 83. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2022.
All research outputs
#521,903
of 25,743,152 outputs
Outputs from Cancer Discovery
#271
of 4,154 outputs
Outputs of similar age
#11,311
of 364,672 outputs
Outputs of similar age from Cancer Discovery
#11
of 105 outputs
Altmetric has tracked 25,743,152 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,154 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,672 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.