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Mendeley readers
Attention Score in Context
| Title |
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci
|
|---|---|
| Published in |
Nature Neuroscience, November 2015
|
| DOI | 10.1038/nn.4182 |
| Pubmed ID | |
| Authors |
Eilis Hannon, Helen Spiers, Joana Viana, Ruth Pidsley, Joe Burrage, Therese M Murphy, Claire Troakes, Gustavo Turecki, Michael C O'Donovan, Leonard C Schalkwyk, Nicholas J Bray, Jonathan Mill |
| Abstract |
We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n = 166) of human fetal brain samples spanning 56-166 d post-conception, identifying >16,000 fetal brain mQTLs. Fetal brain mQTLs were primarily cis-acting, enriched in regulatory chromatin domains and transcription factor binding sites, and showed substantial overlap with genetic variants that were also associated with gene expression in the brain. Using tissue from three distinct regions of the adult brain (prefrontal cortex, striatum and cerebellum), we found that most fetal brain mQTLs were developmentally stable, although a subset was characterized by fetal-specific effects. Fetal brain mQTLs were enriched amongst risk loci identified in a recent large-scale genome-wide association study (GWAS) of schizophrenia, a severe psychiatric disorder with a hypothesized neurodevelopmental component. Finally, we found that mQTLs can be used to refine GWAS loci through the identification of discrete sites of variable fetal brain methylation associated with schizophrenia risk variants. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 23% |
| United Kingdom | 5 | 16% |
| Canada | 3 | 10% |
| Argentina | 1 | 3% |
| Japan | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Ireland | 1 | 3% |
| France | 1 | 3% |
| Spain | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 10 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 61% |
| Scientists | 9 | 29% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 320 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| United Kingdom | 3 | <1% |
| Czechia | 1 | <1% |
| Switzerland | 1 | <1% |
| China | 1 | <1% |
| Canada | 1 | <1% |
| Japan | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 305 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 88 | 28% |
| Researcher | 63 | 20% |
| Student > Master | 34 | 11% |
| Student > Bachelor | 21 | 7% |
| Student > Doctoral Student | 15 | 5% |
| Other | 43 | 13% |
| Unknown | 56 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 85 | 27% |
| Biochemistry, Genetics and Molecular Biology | 68 | 21% |
| Neuroscience | 37 | 12% |
| Medicine and Dentistry | 19 | 6% |
| Psychology | 11 | 3% |
| Other | 28 | 9% |
| Unknown | 72 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 104. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2023.
All research outputs
#410,773
of 25,837,817 outputs
Outputs from Nature Neuroscience
#759
of 5,675 outputs
Outputs of similar age
#6,510
of 398,906 outputs
Outputs of similar age from Nature Neuroscience
#15
of 84 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,675 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 398,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.