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Mesoporous silica formulation strategies for drug dissolution enhancement: a review

Overview of attention for article published in Expert Opinion on Drug Delivery, November 2015
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Title
Mesoporous silica formulation strategies for drug dissolution enhancement: a review
Published in
Expert Opinion on Drug Delivery, November 2015
DOI 10.1517/17425247.2016.1100165
Pubmed ID
Authors

Carol A. McCarthy, Robert J. Ahern, Rakesh Dontireddy, Katie B. Ryan, Abina M. Crean

Abstract

Silica materials, in particular mesoporous silicas, have demonstrated excellent properties to enhance the oral bioavailability of poorly water-soluble drugs. Current research in this area is focused on investigating the kinetic profile of drug release from these carriers and manufacturing approaches to scale-up production for commercial manufacture. Areas covered: This review provides an overview of different methods utilized to load drugs onto mesoporous silica carriers. The influence of silica properties and silica pore architecture on drug loading and release are discussed. The kinetics of drug release from mesoporous silica systems is examined and the manufacturability and stability of these formulations are reviewed. Finally, the future prospects of mesoporous silica drug delivery systems are considered. Expert opinion: Substantial progress has been made in the characterization and development of mesoporous drug delivery systems for drug dissolution enhancement. However, more research is required to fully understand the drug release kinetic profile from mesoporous silica materials. Incomplete drug release from the carrier and the possibility of drug re-adsorption onto the silica surface need to be investigated. Issues to be addressed include the manufacturability and regulation status of formulation approaches employing mesoporous silica to enhance drug dissolution. While more research is needed to support the move of this technology from the bench to a commercial medicinal product, it is a realistic prospect for the near future.

Mendeley readers

The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 <1%
Unknown 174 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 38 22%
Student > Ph. D. Student 35 20%
Researcher 15 9%
Student > Bachelor 12 7%
Other 7 4%
Other 21 12%
Unknown 47 27%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 53 30%
Chemistry 19 11%
Materials Science 8 5%
Chemical Engineering 8 5%
Biochemistry, Genetics and Molecular Biology 7 4%
Other 24 14%
Unknown 56 32%