Title |
WNT Signaling in Cancer Immunosurveillance
|
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Published in |
Trends in Cell Biology, September 2018
|
DOI | 10.1016/j.tcb.2018.08.005 |
Pubmed ID | |
Authors |
Lorenzo Galluzzi, Stefani Spranger, Elaine Fuchs, Alejandro López-Soto |
Abstract |
Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoevasion and resistance to multiple immunotherapeutics, including immune checkpoint blockers. Here, we discuss the molecular and cellular mechanisms through which WNT signaling influences cancer immunosurveillance and present potential therapeutic avenues to harness currently available WNT modulators for cancer immunotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 5 | 26% |
United Kingdom | 2 | 11% |
Singapore | 1 | 5% |
Japan | 1 | 5% |
Spain | 1 | 5% |
Switzerland | 1 | 5% |
Iraq | 1 | 5% |
Unknown | 7 | 37% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 74% |
Scientists | 4 | 21% |
Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 196 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 19% |
Student > Bachelor | 25 | 13% |
Researcher | 24 | 12% |
Other | 15 | 8% |
Student > Doctoral Student | 13 | 7% |
Other | 33 | 17% |
Unknown | 48 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 62 | 32% |
Medicine and Dentistry | 23 | 12% |
Agricultural and Biological Sciences | 18 | 9% |
Immunology and Microbiology | 11 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 21 | 11% |
Unknown | 55 | 28% |