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X Demographics
Mendeley readers
Attention Score in Context
| Title |
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
|
|---|---|
| Published in |
Nature Immunology, December 2015
|
| DOI | 10.1038/ni.3333 |
| Pubmed ID | |
| Authors |
Hexin Shi, Ying Wang, Xiaohong Li, Xiaoming Zhan, Miao Tang, Maggy Fina, Lijing Su, David Pratt, Chun Hui Bu, Sara Hildebrand, Stephen Lyon, Lindsay Scott, Jiexia Quan, Qihua Sun, Jamie Russell, Stephanie Arnett, Peter Jurek, Ding Chen, Vladimir V Kravchenko, John C Mathison, Eva Marie Y Moresco, Nancy L Monson, Richard J Ulevitch, Bruce Beutler |
| Abstract |
The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines, including interleukin 1β (IL-1β) and IL-18. We found here that activation of the NLRP3 inflammasome was restricted to interphase of the cell cycle by NEK7, a serine-threonine kinase previously linked to mitosis. Activation of the NLRP3 inflammasome required NEK7, which bound to the leucine-rich repeat domain of NLRP3 in a kinase-independent manner downstream of the induction of mitochondrial reactive oxygen species (ROS). This interaction was necessary for the formation of a complex containing NLRP3 and the adaptor ASC, oligomerization of ASC and activation of caspase-1. NEK7 promoted the NLRP3-dependent cellular inflammatory response to intraperitoneal challenge with monosodium urate and the development of experimental autoimmune encephalitis in mice. Our findings suggest that NEK7 serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| Netherlands | 1 | 11% |
| United Kingdom | 1 | 11% |
| Germany | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 431 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | <1% |
| China | 1 | <1% |
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 426 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 101 | 23% |
| Student > Master | 60 | 14% |
| Researcher | 53 | 12% |
| Student > Bachelor | 44 | 10% |
| Student > Doctoral Student | 28 | 6% |
| Other | 51 | 12% |
| Unknown | 94 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 88 | 20% |
| Biochemistry, Genetics and Molecular Biology | 87 | 20% |
| Immunology and Microbiology | 63 | 15% |
| Medicine and Dentistry | 30 | 7% |
| Neuroscience | 18 | 4% |
| Other | 44 | 10% |
| Unknown | 101 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2023.
All research outputs
#713,047
of 25,837,817 outputs
Outputs from Nature Immunology
#470
of 4,229 outputs
Outputs of similar age
#11,753
of 399,665 outputs
Outputs of similar age from Nature Immunology
#8
of 59 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,229 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,665 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.