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X Demographics
Mendeley readers
Attention Score in Context
| Title |
SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment
|
|---|---|
| Published in |
Nature Communications, December 2015
|
| DOI | 10.1038/ncomms10004 |
| Pubmed ID | |
| Authors |
Syed A. Mian, Kevin Rouault-Pierre, Alexander E. Smith, Thomas Seidl, Irene Pizzitola, Aytug Kizilors, Austin G. Kulasekararaj, Dominique Bonnet, Ghulam J. Mufti |
| Abstract |
Despite the recent evidence of the existence of myelodysplastic syndrome (MDS) stem cells in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be the initiating cells in other MDS subgroups. Here we demonstrate that SF3B1 mutation(s) in our cohort of MDS patients with ring sideroblasts can arise from CD34(+)CD38(-)CD45RA(-)CD90(+)CD49f(+) HSCs and is an initiating event in disease pathogenesis. Xenotransplantation of SF3B1 mutant HSCs leads to persistent long-term engraftment restricted to myeloid lineage. Moreover, genetically diverse evolving subclones of mutant SF3B1 exist in mice, indicating a branching multi-clonal as well as ancestral evolutionary paradigm. Subclonal evolution in mice is also seen in the clinical evolution in patients. Sequential sample analysis shows clonal evolution and selection of the malignant driving clone leading to AML transformation. In conclusion, our data show SF3B1 mutations can propagate from HSCs to myeloid progeny, therefore providing a therapeutic target. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 4% |
| Unknown | 78 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 32% |
| Researcher | 15 | 19% |
| Other | 6 | 7% |
| Student > Master | 5 | 6% |
| Student > Bachelor | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 17 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 32% |
| Medicine and Dentistry | 18 | 22% |
| Agricultural and Biological Sciences | 14 | 17% |
| Arts and Humanities | 1 | 1% |
| Immunology and Microbiology | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 18 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2023.
All research outputs
#3,397,965
of 23,556,846 outputs
Outputs from Nature Communications
#30,583
of 49,023 outputs
Outputs of similar age
#59,167
of 392,081 outputs
Outputs of similar age from Nature Communications
#384
of 677 outputs
Altmetric has tracked 23,556,846 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,023 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 392,081 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 677 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.