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The intrinsic resistome of Klebsiella pneumoniae

Overview of attention for article published in International Journal of Antimicrobial Agents, January 2019
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

twitter
13 tweeters

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25 Mendeley
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Title
The intrinsic resistome of Klebsiella pneumoniae
Published in
International Journal of Antimicrobial Agents, January 2019
DOI 10.1016/j.ijantimicag.2018.09.012
Pubmed ID
Authors

Alejandra Bernardini, Trinidad Cuesta, Anna Tomás, José A. Bengoechea, José L. Martínez, María B. Sánchez

Abstract

Molecular epidemiology studies aiming at understanding the acquisition of resistance by clinical isolates of Klebsiella pneumoniae are regularly published; however, information on the genes that contribute to its characteristic phenotype of susceptibility to antibiotics (intrinsic resistome) is scarce. To fill this gap, a K. pneumoniae transposon mutants' library was screened and 171 mutants presenting changes in their susceptibility to antibiotics were selected. The transposon insertion site was determined in 75 of them. Twenty-seven mutants, for which insertion points had been previously identified, were included in the analysis. One hundred and two mutants were selected for further studies. In 70 of them the transposon was inserted in a gene with a known function, while in 19 the insertion occurred in genes encoding proteins with unknown functions and 13 insertions occurred in intergenic regions. Eighty-seven of the insertions were localized in the chromosome, with 15 insertions located in the two plasmids carried by this strain. Whereas some of the mutated genes are already known to be involved in antibiotic resistance (ampG, acrB, tolC), several of them are involved in regular processes of bacterial physiology, including K. pneumoniae virulence. Together with results published for other organisms, our results support that determinants involved in basic processes of the bacterial physiology may contribute to antibiotic resistance. Our findings also indicate that, besides acquired resistance genes, plasmids may harbour other genes belonging to their backbone that can also be involved in resistance.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 20%
Student > Bachelor 5 20%
Researcher 5 20%
Lecturer 3 12%
Student > Doctoral Student 2 8%
Other 5 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 36%
Unspecified 6 24%
Medicine and Dentistry 3 12%
Agricultural and Biological Sciences 3 12%
Immunology and Microbiology 2 8%
Other 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2018.
All research outputs
#2,214,085
of 12,713,955 outputs
Outputs from International Journal of Antimicrobial Agents
#218
of 1,773 outputs
Outputs of similar age
#71,709
of 263,617 outputs
Outputs of similar age from International Journal of Antimicrobial Agents
#8
of 48 outputs
Altmetric has tracked 12,713,955 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,773 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,617 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.