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Discovery of a periosteal stem cell mediating intramembranous bone formation

Overview of attention for article published in Nature, September 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)

Mentioned by

news
2 news outlets
twitter
22 tweeters

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
144 Mendeley
Title
Discovery of a periosteal stem cell mediating intramembranous bone formation
Published in
Nature, September 2018
DOI 10.1038/s41586-018-0554-8
Pubmed ID
Authors

Shawon Debnath, Alisha R. Yallowitz, Jason McCormick, Sarfaraz Lalani, Tuo Zhang, Ren Xu, Na Li, Yifang Liu, Yeon Suk Yang, Mark Eiseman, Jae-Hyuck Shim, Meera Hameed, John H. Healey, Mathias P. Bostrom, Dan Avi Landau, Matthew B. Greenblatt

Abstract

Bone consists of separate inner endosteal and outer periosteal compartments, each with distinct contributions to bone physiology and each maintaining separate pools of cells owing to physical separation by the bone cortex. The skeletal stem cell that gives rise to endosteal osteoblasts has been extensively studied; however, the identity of periosteal stem cells remains unclear1-5. Here we identify a periosteal stem cell (PSC) that is present in the long bones and calvarium of mice, displays clonal multipotency and self-renewal, and sits at the apex of a differentiation hierarchy. Single-cell and bulk transcriptional profiling show that PSCs display transcriptional signatures that are distinct from those of other skeletal stem cells and mature mesenchymal cells. Whereas other skeletal stem cells form bone via an initial cartilage template using the endochondral pathway4, PSCs form bone via a direct intramembranous route, providing a cellular basis for the divergence between intramembranous versus endochondral developmental pathways. However, there is plasticity in this division, as PSCs acquire endochondral bone formation capacity in response to injury. Genetic blockade of the ability of PSCs to give rise to bone-forming osteoblasts results in selective impairments in cortical bone architecture and defects in fracture healing. A cell analogous to mouse PSCs is present in the human periosteum, raising the possibility that PSCs are attractive targets for drug and cellular therapy for skeletal disorders. The identification of PSCs provides evidence that bone contains multiple pools of stem cells, each with distinct physiologic functions.

Twitter Demographics

The data shown below were collected from the profiles of 22 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 144 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 22%
Student > Ph. D. Student 31 22%
Student > Master 13 9%
Student > Bachelor 13 9%
Student > Doctoral Student 12 8%
Other 23 16%
Unknown 20 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 42 29%
Medicine and Dentistry 28 19%
Agricultural and Biological Sciences 28 19%
Engineering 6 4%
Neuroscience 3 2%
Other 10 7%
Unknown 27 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2019.
All research outputs
#611,357
of 13,703,906 outputs
Outputs from Nature
#23,491
of 70,433 outputs
Outputs of similar age
#21,870
of 266,412 outputs
Outputs of similar age from Nature
#790
of 1,024 outputs
Altmetric has tracked 13,703,906 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 70,433 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 77.4. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,412 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 1,024 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.