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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mechanisms for estrogen receptor expression in human cancer
|
|---|---|
| Published in |
Experimental Hematology & Oncology, September 2018
|
| DOI | 10.1186/s40164-018-0116-7 |
| Pubmed ID | |
| Authors |
Hui Hua, Hongying Zhang, Qingbin Kong, Yangfu Jiang |
| Abstract |
Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis. Estrogen antagonists and drugs that reduce estrogen biosynthesis have become highly successful therapeutic agents for breast cancer patients. The effects of estrogen are largely mediated by estrogen receptor (ER) α and ERβ, which are members of the nuclear receptor superfamily of transcription factors. The mechanisms underlying the aberrant expression of ER in breast cancer and other types of human tumors are complex, involving considerable alternative splicing of ERα and ERβ, transcription factors, epigenetic and post-transcriptional regulation of ER expression. Elucidation of mechanisms for ER expression may not only help understand cancer progression and evolution, but also shed light on overcoming endocrine therapy resistance. Herein, we review the complex mechanisms for regulating ER expression in human cancer. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 189 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 189 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 13% |
| Student > Master | 23 | 12% |
| Student > Ph. D. Student | 19 | 10% |
| Researcher | 14 | 7% |
| Student > Postgraduate | 14 | 7% |
| Other | 24 | 13% |
| Unknown | 70 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 41 | 22% |
| Medicine and Dentistry | 16 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 7% |
| Agricultural and Biological Sciences | 11 | 6% |
| Chemistry | 9 | 5% |
| Other | 23 | 12% |
| Unknown | 75 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2023.
All research outputs
#14,218,560
of 23,911,072 outputs
Outputs from Experimental Hematology & Oncology
#119
of 325 outputs
Outputs of similar age
#177,905
of 345,161 outputs
Outputs of similar age from Experimental Hematology & Oncology
#5
of 6 outputs
Altmetric has tracked 23,911,072 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 325 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,161 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.