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Infectious dose and repeated infections are key factors influencing immune response characteristics in guinea pig ocular chlamydial infection

Overview of attention for article published in Microbes & Infection, April 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
10 tweeters

Citations

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7 Dimensions

Readers on

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23 Mendeley
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Title
Infectious dose and repeated infections are key factors influencing immune response characteristics in guinea pig ocular chlamydial infection
Published in
Microbes & Infection, April 2016
DOI 10.1016/j.micinf.2015.12.001
Pubmed ID
Authors

Sandra Belij-Rammerstorfer, Aleksandra Inic-Kanada, Marijana Stojanovic, Emilija Marinkovic, Ivana Lukic, Elisabeth Stein, Jacqueline Montanaro, Nora Bintner, Nadine Schürer, Ehsan Ghasemian, Michael Kundi, Talin Barisani-Asenbauer

Abstract

The aim of this study was to determine whether infectious dose of Chlamydia caviae after repeated infections influences the immunological responses and subsequent clearance of pathogen at the ocular surface of guinea pigs. Animals were infected three times via the conjunctiva at six- and twelve-week intervals by applying either 1 × 10(4) or 1 × 10(6) inclusion-forming units (IFUs) of C. caviae. Ocular pathology, infection course, C. caviae-specific serum IgG levels and their capacity to bind and neutralize infection ex vivo were assessed. Animals infected with 1 × 10(4) IFUs had completely diminished ocular infection and pathology after the 2(nd) infection with increased levels of C. caviae-specific serum IgG and their effective capacity to bind and neutralize C. caviae. Only partial protection was observed in animals infected with 1 × 10(6) IFUs after the 2(nd) and 3(rd) infections. Our findings show that full protection was observed in animals repeatedly infected with the lower dose. The lower dose appeared not to compromise the host immune system, thereby enabling fast clearance of the pathogen and the establishment of competent neutralizing antibodies.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 30%
Student > Master 5 22%
Student > Ph. D. Student 3 13%
Professor > Associate Professor 2 9%
Student > Doctoral Student 1 4%
Other 0 0%
Unknown 5 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 17%
Veterinary Science and Veterinary Medicine 3 13%
Immunology and Microbiology 3 13%
Agricultural and Biological Sciences 2 9%
Nursing and Health Professions 2 9%
Other 2 9%
Unknown 7 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2016.
All research outputs
#5,272,243
of 21,376,549 outputs
Outputs from Microbes & Infection
#639
of 1,848 outputs
Outputs of similar age
#93,396
of 400,815 outputs
Outputs of similar age from Microbes & Infection
#12
of 18 outputs
Altmetric has tracked 21,376,549 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,848 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,815 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.