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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Infectious dose and repeated infections are key factors influencing immune response characteristics in guinea pig ocular chlamydial infection
|
|---|---|
| Published in |
Microbes & Infection, December 2015
|
| DOI | 10.1016/j.micinf.2015.12.001 |
| Pubmed ID | |
| Authors |
Sandra Belij-Rammerstorfer, Aleksandra Inic-Kanada, Marijana Stojanovic, Emilija Marinkovic, Ivana Lukic, Elisabeth Stein, Jacqueline Montanaro, Nora Bintner, Nadine Schürer, Ehsan Ghasemian, Michael Kundi, Talin Barisani-Asenbauer |
| Abstract |
The aim of this study was to determine whether infectious dose of Chlamydia caviae after repeated infections influences the immunological responses and subsequent clearance of pathogen at the ocular surface of guinea pigs. Animals were infected three times via the conjunctiva at six- and twelve-week intervals by applying either 1 × 10(4) or 1 × 10(6) inclusion-forming units (IFUs) of C. caviae. Ocular pathology, infection course, C. caviae-specific serum IgG levels and their capacity to bind and neutralize infection ex vivo were assessed. Animals infected with 1 × 10(4) IFUs had completely diminished ocular infection and pathology after the 2(nd) infection with increased levels of C. caviae-specific serum IgG and their effective capacity to bind and neutralize C. caviae. Only partial protection was observed in animals infected with 1 × 10(6) IFUs after the 2(nd) and 3(rd) infections. Our findings show that full protection was observed in animals repeatedly infected with the lower dose. The lower dose appeared not to compromise the host immune system, thereby enabling fast clearance of the pathogen and the establishment of competent neutralizing antibodies. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 10% |
| Ecuador | 1 | 10% |
| United Kingdom | 1 | 10% |
| Venezuela, Bolivarian Republic of | 1 | 10% |
| Kenya | 1 | 10% |
| United States | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 40% |
| Members of the public | 4 | 40% |
| Practitioners (doctors, other healthcare professionals) | 2 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 32% |
| Student > Master | 4 | 18% |
| Student > Ph. D. Student | 3 | 14% |
| Professor > Associate Professor | 2 | 9% |
| Student > Doctoral Student | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 5 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 3 | 14% |
| Biochemistry, Genetics and Molecular Biology | 3 | 14% |
| Immunology and Microbiology | 3 | 14% |
| Agricultural and Biological Sciences | 2 | 9% |
| Nursing and Health Professions | 2 | 9% |
| Other | 2 | 9% |
| Unknown | 7 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2016.
All research outputs
#6,535,888
of 25,394,764 outputs
Outputs from Microbes & Infection
#689
of 1,999 outputs
Outputs of similar age
#89,791
of 380,268 outputs
Outputs of similar age from Microbes & Infection
#14
of 26 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,999 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 380,268 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.