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The relationship between plasma Aβ levels, cognitive function and brain volumetrics: Sydney Memory and Ageing Study.

Overview of attention for article published in Current Alzheimer Research, December 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 673)
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
5 news outlets

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
29 Mendeley
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Title
The relationship between plasma Aβ levels, cognitive function and brain volumetrics: Sydney Memory and Ageing Study.
Published in
Current Alzheimer Research, December 2015
DOI 10.2174/1567205013666151218150202
Pubmed ID
Authors

Poljak, A, Crawford, J D, Smythe, G A, Brodaty, H, Slavin, M J, Kochan, N A, Trollor, J N, Wen, W, Mather, K A, Assareh, A A, Ng, P C, Sachdev, P S, Poljak, Anne, Crawford, John D, Smythe, George A, Brodaty, Henry, Slavin, Melissa J, Kochan, Nicole A, Trollor, Julian N, Wen, Wei, Mather, Karen A, Assareh, Amelia A, Ng, Pek C, Sachdev, Perminder S, Anne Poljak, John Crawford, George Smythe, Henry Brodaty, Melissa Slavin, Nicole Kochan, Julian Trollor, Wei Wen, Karen Mather, Amelia Assareh, Pek Ng, Perminder Sachdev, A Poljak, JD Crawford, GA Smythe, H Brodaty, MJ Slavin, NA Kochan, JN Trollor, W Wen, KA Mather, AA Assareh, PC Ng, PS Sachdev

Abstract

Objectives Determine whether (1) a relationship exists between plasma amyloid-β (Aβ1-40 and 1-42 peptide levels, brain volumetrics and cognitive performance in elderly individuals with and without amnestic mild cognitive impairment (aMCI), (2) plasma Aβ peptide levels differ between apolipoprotein E (APOE) β4 carriers and non-carriers and (3) longitudinal changes in cognition and brain volume relate to Aβ levels. Methods Subjects with aMCI (n = 89) and normal cognition (n = 126) were drawn from the Sydney Memory and Aging Study (Sydney MAS), a population based study of non-demented 70-90 year old individuals; 39 Alzheimer's disease (AD) patients were recruited from a specialty clinic. Sydney MAS participants underwent brain MRI scans and were assessed on 19 cognitive measures and were APOE β4 genotyped. Plasma levels of Aβ1-40 and 1-42 were quantified using ELISA. Results Wave1 plasma levels of A peptides and Aβ 42/1-40 ratio were lower in aMCI and AD, and Aβ 42 was positively associated with global cognition and hippocampal volume and negatively with white matter hyperintensities. The relationships of Aβ1-40 and Aβ1-42 were predominantly observed in β4 allele carriers and non-carriers respectively. Longitudinal analysis revealed greater decline in global cognition and memory for the highest quintiles of Aβ42 and the ratio measure. Conclusions Plasma Aβ levels and the Aβ42/1-40 ratio are related to cognition and hippocampal volumes, with differential associations of Aβ1-40 and Aβ1-42 in β4 carriers and non-carriers. These data support the Aβ sink model of AD pathology, and suggest that plasma Aβ measures may serve as biomarkers of AD.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
New Zealand 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 17%
Researcher 5 17%
Student > Master 5 17%
Student > Ph. D. Student 4 14%
Professor 3 10%
Other 7 24%
Readers by discipline Count As %
Neuroscience 8 28%
Unspecified 5 17%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 3 10%
Psychology 3 10%
Other 6 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2016.
All research outputs
#336,574
of 11,426,369 outputs
Outputs from Current Alzheimer Research
#3
of 673 outputs
Outputs of similar age
#14,578
of 323,079 outputs
Outputs of similar age from Current Alzheimer Research
#1
of 41 outputs
Altmetric has tracked 11,426,369 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 673 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,079 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.