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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
|
|---|---|
| Published in |
Scientific Reports, December 2011
|
| DOI | 10.1038/srep00189 |
| Pubmed ID | |
| Authors |
María Guillamot, Eusebio Manchado, Massimo Chiesa, Gonzalo Gómez-López, David G. Pisano, María P. Sacristán, Marcos Malumbres |
| Abstract |
Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| France | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Portugal | 1 | 2% |
| Belgium | 1 | 2% |
| Unknown | 52 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 38% |
| Researcher | 11 | 20% |
| Student > Master | 6 | 11% |
| Student > Bachelor | 4 | 7% |
| Student > Doctoral Student | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 49% |
| Biochemistry, Genetics and Molecular Biology | 13 | 24% |
| Neuroscience | 2 | 4% |
| Immunology and Microbiology | 1 | 2% |
| Arts and Humanities | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2012.
All research outputs
#13,126,617
of 22,659,164 outputs
Outputs from Scientific Reports
#57,918
of 122,016 outputs
Outputs of similar age
#145,805
of 242,260 outputs
Outputs of similar age from Scientific Reports
#53
of 101 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 122,016 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,260 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.