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Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome

Overview of attention for article published in Revista da Associação Médica Brasileira, June 2015
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Title
Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome
Published in
Revista da Associação Médica Brasileira, June 2015
DOI 10.1590/1806-9282.61.03.215
Pubmed ID
Authors

Margareth Chiharu Iwata, Livia Porquere, Isabel C. Espósito Sorpreso, Edmund C. Baracat, José Maria Soares Júnior

Abstract

to compare clinical and laboratory parameters in women with polycystic ovary syndrome (PCOS) using metformin or combined oral contraceptive (COC) after 6 months. retrospective study analyzing records of patients with PCOS using the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society criteria. The groups were: I-COC (21 tablets, pause of 7 days; n=16); II-metformin (850mg 12/12h, n=16); III-COC plus metformin (n=9). Body mass index (BMI), acne (% of improvement), modified Ferriman-Gallway index and menstrual cycle index (MCI), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (TT), androstenedione (A) and homeostasis model assessment: insulin resistance (HOMA-IR) index were assessed Results: isolated use of COC compared to metformin was better regarding to acne, Ferriman index, MCI, LH, TT and A levels. On the other hand, metformin was better in the HOMA-IR index (4.44 and 1.67 respectively, p=0.0007). The association COC plus metformin, compared to metformin alone shows the maintenance of improvement of acne, Ferriman index, MCI, and testosterone levels. The HOMA-IR index remained lower in the metformin alone group (4.19 and 1.67, respectively; p=0,046). The comparison between COC plus metformin and COC alone, in turn, shows no difference in the improvement of acne, Ferriman index, MCI, LH, TT and A levels, indicating that the inclusion of metformin did not lead to additional benefits in these parameters. Still, the HOMA-IR index was similar in both groups (4.19 and 4.44 respectively; p=0.75), showing that the use of metformin associated with COC may not improve insulin resistance as much as it does if used alone. our data suggest that the combination of metformin and contraceptive does not improve insulin resistance as observed with metformin alone.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 27%
Researcher 5 10%
Student > Postgraduate 4 8%
Student > Doctoral Student 4 8%
Librarian 3 6%
Other 13 27%
Unknown 7 14%
Readers by discipline Count As %
Medicine and Dentistry 19 39%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Agricultural and Biological Sciences 4 8%
Biochemistry, Genetics and Molecular Biology 4 8%
Social Sciences 3 6%
Other 5 10%
Unknown 10 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2015.
All research outputs
#5,049,229
of 6,797,067 outputs
Outputs from Revista da Associação Médica Brasileira
#199
of 333 outputs
Outputs of similar age
#199,085
of 293,352 outputs
Outputs of similar age from Revista da Associação Médica Brasileira
#3
of 4 outputs
Altmetric has tracked 6,797,067 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 333 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,352 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.