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Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition.

Overview of attention for article published in Acta Cirurgica Brasileira, June 2015
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Title
Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition.
Published in
Acta Cirurgica Brasileira, June 2015
DOI 10.1590/s0102-865020150060000003
Pubmed ID
Authors

Macedo, Robson, Javadi, Som Mehrbod, Higuchi, Takahiro, Carvalho, Marília Daniela Ferreira de, Medeiros, Vanessa de Fátima Lima Paiva, Azevedo, Ítalo Medeiros, Lima, Francisco Pignataro, Medeiros, Aldo Cunha

Abstract

To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis. Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hours after cecal ligation and puncture rats received 1.0MBq of Tc-99m-sestamibi i.v. 30min after, animals were euthanized for ex-vivo tissue counting and myocardium histological analysis. Myocardial histologic alterations were not detected 24 hours post-sepsis. There was significantly increased cardiac Tc-99m-sestamibi activity in the sepsis group with simvastatin treatment (1.9±0.3%ID/g, p<0.001) in comparison to the sepsis group+vehicle (1.0±0.2%ID/g), control sham group+ simvastatin (1.2±0.3%ID/g) and control sham group (1.3±0.2%ID/g). Significant Tc-99m-sestamibi activity in liver, kidney and lungs was also detected in the sepsis group treated with simvastatinin comparison to the other groups. Statin treatment altered the biodistribution of Tc-99m-sestamibi with increased cardiac and solid organ activity in rats with abdominal sepsis, while no impact on controls. Increased myocardial tracer activity may be a result of a possible protection effect due to increased tissue perfusion mediated by statins.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 21%
Student > Postgraduate 2 14%
Student > Bachelor 2 14%
Professor 1 7%
Student > Ph. D. Student 1 7%
Other 3 21%
Unknown 2 14%
Readers by discipline Count As %
Medicine and Dentistry 7 50%
Pharmacology, Toxicology and Pharmaceutical Science 2 14%
Nursing and Health Professions 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Unknown 3 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2015.
All research outputs
#5,832,451
of 6,818,838 outputs
Outputs from Acta Cirurgica Brasileira
#42
of 86 outputs
Outputs of similar age
#239,696
of 295,531 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#5
of 14 outputs
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.