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Nanostructured ultra-thin patches for ultrasound-modulated delivery of anti-restenotic drug

Overview of attention for article published in International Journal of Nanomedicine, December 2015
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

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4 tweeters
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1 Google+ user

Citations

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23 Dimensions

Readers on

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36 Mendeley
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Title
Nanostructured ultra-thin patches for ultrasound-modulated delivery of anti-restenotic drug
Published in
International Journal of Nanomedicine, December 2015
DOI 10.2147/ijn.s92031
Pubmed ID
Authors

Lorenzo Vannozzi, Leonardo Ricotti, Carlo Filippeschi, Stefania Sartini, Vito Coviello, Vincenzo Piazza, Pasqualantonio Pingue, Concettina La Motta, Paolo Dario, Arianna Menciassi

Abstract

This work aims to demonstrate the possibility to fabricate ultra-thin polymeric films loaded with an anti-restenotic drug and capable of tunable drug release kinetics for the local treatment of restenosis. Vascular nanopatches are composed of a poly(lactic acid) supporting membrane (thickness: ~250 nm) on which 20 polyelectrolyte bilayers (overall thickness: ~70 nm) are alternatively deposited. The anti-restenotic drug is embedded in the middle of the polyelectrolyte structure, and released by diffusion mechanisms. Nanofilm fabrication procedure and detailed morphological characterization are reported here. Barium titanate nanoparticles (showing piezoelectric properties) are included in the polymeric support and their role is investigated in terms of influence on nanofilm morphology, drug release kinetics, and cell response. Results show an efficient drug release from the polyelectrolyte structure in phosphate-buffered saline, and a clear antiproliferative effect on human smooth muscle cells, which are responsible for restenosis. In addition, preliminary evidences of ultrasound-mediated modulation of drug release kinetics are reported, thus evaluating the influence of barium titanate nanoparticles on the release mechanism. Such data were integrated with quantitative piezoelectric and thermal measurements. These results open new avenues for a fine control of local therapies based on smart responsive materials.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Slovakia 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 25%
Researcher 7 19%
Student > Master 4 11%
Other 3 8%
Student > Doctoral Student 3 8%
Other 7 19%
Unknown 3 8%
Readers by discipline Count As %
Engineering 10 28%
Materials Science 8 22%
Chemistry 7 19%
Chemical Engineering 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Other 2 6%
Unknown 4 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2015.
All research outputs
#2,486,178
of 6,889,784 outputs
Outputs from International Journal of Nanomedicine
#221
of 1,641 outputs
Outputs of similar age
#95,488
of 296,058 outputs
Outputs of similar age from International Journal of Nanomedicine
#21
of 84 outputs
Altmetric has tracked 6,889,784 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 1,641 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,058 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.