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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease
|
|---|---|
| Published in |
PLOS ONE, December 2011
|
| DOI | 10.1371/journal.pone.0027865 |
| Pubmed ID | |
| Authors |
Qi Chen, Marguerite Prior, Richard Dargusch, Amanda Roberts, Roland Riek, Cédric Eichmann, Chandramouli Chiruta, Tatsuhiro Akaishi, Kazuho Abe, Pamela Maher, David Schubert |
| Abstract |
Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. For Alzheimer's disease (AD), the focus is the amyloid beta peptide (Aß) that mediates familial Alzheimer's disease pathology. However, given that age is the greatest risk factor for AD, we explored an alternative drug discovery scheme that is based upon efficacy in multiple cell culture models of age-associated pathologies rather than exclusively amyloid metabolism. Using this approach, we identified an exceptionally potent, orally active, neurotrophic molecule that facilitates memory in normal rodents, and prevents the loss of synaptic proteins and cognitive decline in a transgenic AD mouse model. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 29% |
| Belgium | 1 | 7% |
| Canada | 1 | 7% |
| Brazil | 1 | 7% |
| Chile | 1 | 7% |
| Unknown | 6 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 86% |
| Scientists | 2 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Spain | 3 | 1% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 203 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 21% |
| Researcher | 35 | 16% |
| Student > Master | 33 | 15% |
| Other | 16 | 7% |
| Student > Bachelor | 14 | 7% |
| Other | 45 | 21% |
| Unknown | 25 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 28% |
| Medicine and Dentistry | 33 | 15% |
| Biochemistry, Genetics and Molecular Biology | 19 | 9% |
| Neuroscience | 15 | 7% |
| Chemistry | 12 | 6% |
| Other | 39 | 18% |
| Unknown | 36 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2022.
All research outputs
#566,281
of 25,654,806 outputs
Outputs from PLOS ONE
#7,733
of 223,967 outputs
Outputs of similar age
#2,920
of 250,346 outputs
Outputs of similar age from PLOS ONE
#77
of 3,021 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 223,967 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 3,021 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.