Andrographolide Prevents EV-D68 Replication by Inhibiting the Acidification of Virus-Containing Endocytic Vesicles

https://t.co/eGegZ7oaha

https://t.co/Cq5G4Fw79F "Finally, we showed that ADO inhibited the viral replication of circulating isolated EV-D68 strains." "In summary, our results demonstrate that ADO suppresses EV-D68 replication by targeting the maturation of virus-containing endo

https://t.co/Cq5G4Fw79F "ADO treatment dramatically inhibited EV-D68 RNA replication (EC50 = 3.45 μM) and protein synthesis without producing significant cytotoxicity at virucidal concentrations."

https://t.co/Cq5G4Fw79F "In this study, we demonstrate that andrographolide (ADO), an active component of Andrographis paniculata, exerts substantial antiviral activity against EV-D68 infection."