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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons
|
|---|---|
| Published in |
Nucleic Acids Research, December 2015
|
| DOI | 10.1093/nar/gkv1512 |
| Pubmed ID | |
| Authors |
José García-Martínez, Lidia Delgado-Ramos, Guillermo Ayala, Vicent Pelechano, Daniel A. Medina, Fany Carrasco, Ramón González, Eduardo Andrés-León, Lars Steinmetz, Jonas Warringer, Sebastián Chávez, José E. Pérez-Ortín |
| Abstract |
We analyzed 80 different genomic experiments, and found a positive correlation between both RNA polymerase II transcription and mRNA degradation with growth rates in yeast. Thus, in spite of the marked variation in mRNA turnover, the total mRNA concentration remained approximately constant. Some genes, however, regulated their mRNA concentration by uncoupling mRNA stability from the transcription rate. Ribosome-related genes modulated their transcription rates to increase mRNA levels under fast growth. In contrast, mitochondria-related and stress-induced genes lowered mRNA levels by reducing mRNA stability or the transcription rate, respectively. We also detected these regulations within the heterogeneity of a wild-type cell population growing in optimal conditions. The transcriptomic analysis of sorted microcolonies confirmed that the growth rate dictates alternative expression programs by modulating transcription and mRNA decay.The regulation of overall mRNA turnover keeps a constant ratio between mRNA decay and the dilution of [mRNA] caused by cellular growth. This regulation minimizes the indiscriminate transmission of mRNAs from mother to daughter cells, and favors the response capacity of the latter to physiological signals and environmental changes. We also conclude that, by uncoupling mRNA synthesis from decay, cells control the mRNA abundance of those gene regulons that characterize fast and slow growth. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 27% |
| France | 2 | 18% |
| United States | 2 | 18% |
| Unknown | 4 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Scientists | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| China | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 130 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 29% |
| Researcher | 20 | 15% |
| Student > Master | 12 | 9% |
| Student > Bachelor | 9 | 7% |
| Professor | 7 | 5% |
| Other | 23 | 17% |
| Unknown | 26 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 44 | 32% |
| Agricultural and Biological Sciences | 39 | 29% |
| Engineering | 5 | 4% |
| Computer Science | 3 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 16 | 12% |
| Unknown | 27 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2020.
All research outputs
#4,427,184
of 22,836,570 outputs
Outputs from Nucleic Acids Research
#6,812
of 26,327 outputs
Outputs of similar age
#77,303
of 392,772 outputs
Outputs of similar age from Nucleic Acids Research
#143
of 354 outputs
Altmetric has tracked 22,836,570 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,327 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 392,772 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 354 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.