The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia
|
|---|---|
| Published in |
Cancer Discovery, March 2016
|
| DOI | 10.1158/2159-8290.cd-15-0822 |
| Pubmed ID | |
| Authors |
Kyoung Eun Lee, Michelle Spata, Lauren J Bayne, Elizabeth L Buza, Amy C Durham, David Allman, Robert H Vonderheide, M Celeste Simon |
| Abstract |
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths worldwide, with an exceedingly low 5-year survival rate. PDAC tumors are characterized by an extensive desmoplastic stromal response and hypovascularity, suggesting that tumor hypoxia could regulate PDAC initiation and/or progression. Using a well-defined, autochthonous KrasG12D-driven murine model, as well as human tumors, we demonstrate that hypoxia and stabilization of hypoxia-inducible factor 1α (HIF1α), a principal mediator of hypoxic adaptation, emerge early during preinvasive stages of PDAC. Surprisingly, pancreas-specific Hif1α deletion drastically accelerated KrasG12D-driven pancreatic neoplasia, and was accompanied by significant increases in intrapancreatic B lymphocytes, featuring prominent influx of a rare "B1b" B cell subtype. Finally, treatment of HIF1α-deficient mice with B cell-depleting αCD20 monoclonal antibodies inhibited progression of pancreatic intraepithelial neoplasia (PanIN). Our data reveal a previously unrecognized role for B cells in promoting pancreatic tumorigenesis, and implicate HIF1α as a critical regulator of PDAC development. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 19% |
| Germany | 1 | 5% |
| Egypt | 1 | 5% |
| China | 1 | 5% |
| Unknown | 14 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 62% |
| Scientists | 6 | 29% |
| Science communicators (journalists, bloggers, editors) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 145 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 26% |
| Student > Ph. D. Student | 28 | 19% |
| Student > Postgraduate | 10 | 7% |
| Student > Bachelor | 10 | 7% |
| Student > Master | 10 | 7% |
| Other | 24 | 16% |
| Unknown | 27 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 37 | 25% |
| Medicine and Dentistry | 34 | 23% |
| Agricultural and Biological Sciences | 21 | 14% |
| Immunology and Microbiology | 17 | 12% |
| Engineering | 4 | 3% |
| Other | 7 | 5% |
| Unknown | 27 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2023.
All research outputs
#2,781,332
of 26,386,754 outputs
Outputs from Cancer Discovery
#1,122
of 4,214 outputs
Outputs of similar age
#41,449
of 315,470 outputs
Outputs of similar age from Cancer Discovery
#15
of 79 outputs
Altmetric has tracked 26,386,754 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,214 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,470 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.