↓ Skip to main content

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

Overview of attention for article published in Cancer Discovery, March 2016
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

twitter
21 X users
f1000
1 research highlight platform

Citations

dimensions_citation
175 Dimensions

Readers on

mendeley
149 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia
Published in
Cancer Discovery, March 2016
DOI 10.1158/2159-8290.cd-15-0822
Pubmed ID
Authors

Kyoung Eun Lee, Michelle Spata, Lauren J Bayne, Elizabeth L Buza, Amy C Durham, David Allman, Robert H Vonderheide, M Celeste Simon

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths worldwide, with an exceedingly low 5-year survival rate. PDAC tumors are characterized by an extensive desmoplastic stromal response and hypovascularity, suggesting that tumor hypoxia could regulate PDAC initiation and/or progression. Using a well-defined, autochthonous KrasG12D-driven murine model, as well as human tumors, we demonstrate that hypoxia and stabilization of hypoxia-inducible factor 1α (HIF1α), a principal mediator of hypoxic adaptation, emerge early during preinvasive stages of PDAC. Surprisingly, pancreas-specific Hif1α deletion drastically accelerated KrasG12D-driven pancreatic neoplasia, and was accompanied by significant increases in intrapancreatic B lymphocytes, featuring prominent influx of a rare "B1b" B cell subtype. Finally, treatment of HIF1α-deficient mice with B cell-depleting αCD20 monoclonal antibodies inhibited progression of pancreatic intraepithelial neoplasia (PanIN). Our data reveal a previously unrecognized role for B cells in promoting pancreatic tumorigenesis, and implicate HIF1α as a critical regulator of PDAC development.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Netherlands 1 <1%
Unknown 147 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 25%
Student > Ph. D. Student 29 19%
Student > Postgraduate 10 7%
Student > Bachelor 10 7%
Student > Master 10 7%
Other 26 17%
Unknown 27 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 38 26%
Medicine and Dentistry 34 23%
Agricultural and Biological Sciences 21 14%
Immunology and Microbiology 16 11%
Engineering 4 3%
Other 9 6%
Unknown 27 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2023.
All research outputs
#2,625,730
of 25,383,225 outputs
Outputs from Cancer Discovery
#1,051
of 4,053 outputs
Outputs of similar age
#40,207
of 307,895 outputs
Outputs of similar age from Cancer Discovery
#13
of 79 outputs
Altmetric has tracked 25,383,225 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.5. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,895 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.