Title |
Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
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Published in |
Journal of Autism and Developmental Disorders, December 2011
|
DOI | 10.1007/s10803-011-1418-3 |
Pubmed ID | |
Authors |
Beth Malow, Karen W. Adkins, Susan G. McGrew, Lily Wang, Suzanne E. Goldman, Diane Fawkes, Courtney Burnette |
Abstract |
Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose-response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Uruguay | 1 | 17% |
Malaysia | 1 | 17% |
New Zealand | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
Netherlands | 1 | <1% |
Australia | 1 | <1% |
France | 1 | <1% |
Spain | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 330 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 45 | 13% |
Student > Master | 41 | 12% |
Student > Ph. D. Student | 40 | 12% |
Researcher | 37 | 11% |
Other | 24 | 7% |
Other | 70 | 21% |
Unknown | 81 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 84 | 25% |
Psychology | 51 | 15% |
Agricultural and Biological Sciences | 29 | 9% |
Nursing and Health Professions | 17 | 5% |
Neuroscience | 12 | 4% |
Other | 42 | 12% |
Unknown | 103 | 30% |