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Putting the pH into phosphatidic acid signaling

Overview of attention for article published in BMC Biology, December 2011
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Title
Putting the pH into phosphatidic acid signaling
Published in
BMC Biology, December 2011
DOI 10.1186/1741-7007-9-85
Pubmed ID
Authors

John JH Shin, Christopher JR Loewen

Abstract

The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 2 1%
Austria 2 1%
Canada 2 1%
India 1 <1%
Czechia 1 <1%
United Kingdom 1 <1%
Germany 1 <1%
Argentina 1 <1%
China 1 <1%
Other 2 1%
Unknown 146 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 22%
Researcher 31 19%
Student > Bachelor 20 13%
Student > Master 17 11%
Professor > Associate Professor 13 8%
Other 25 16%
Unknown 19 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 70 44%
Biochemistry, Genetics and Molecular Biology 32 20%
Chemistry 13 8%
Neuroscience 4 3%
Medicine and Dentistry 3 2%
Other 13 8%
Unknown 25 16%