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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Type II Secreted Lipase/Esterase LesA is a Key Virulence Factor Required for Xylella fastidiosa Pathogenesis in Grapevines
|
|---|---|
| Published in |
Scientific Reports, January 2016
|
| DOI | 10.1038/srep18598 |
| Pubmed ID | |
| Authors |
Rafael Nascimento, Hossein Gouran, Sandeep Chakraborty, Hyrum W. Gillespie, Hebréia O. Almeida-Souza, Aye Tu, Basuthkar J. Rao, Paul A. Feldstein, George Bruening, Luiz R. Goulart, Abhaya M. Dandekar |
| Abstract |
Pierce's disease (PD) of grapevines is caused by Xylella fastidiosa (Xf), a xylem-limited gamma-proteobacterium that is responsible for several economically important crop diseases. The occlusion of xylem elements and interference with water transport by Xf and its associated biofilm have been posited as the main cause of PD symptom development; however, Xf virulence mechanisms have not been described. Analysis of the Xf secretome revealed a putative lipase/esterase (LesA) that was abundantly secreted in bacterial culture supernatant and was characterized as a protein ortholog of the cell wall-degrading enzyme LipA of Xanthomonas strains. LesA was secreted by Xf and associated with a biofilm filamentous network. Additional proteomic analysis revealed its abundant presence in outer membrane vesicles (OMVs). Accumulation of LesA in leaf regions associated positively with PD symptoms and inversely with bacterial titer. The lipase/esterase also elicited a hypersensitive response in grapevine. Xf lesA mutants were significantly deficient for virulence when mechanically inoculated into grapevines. We propose that Xf pathogenesis is caused by LesA secretion mediated by OMV cargos and that its release and accumulation in leaf margins leads to early stages of observed PD symptoms. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 50% |
| United Kingdom | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 60% |
| Scientists | 3 | 30% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 140 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 17% |
| Researcher | 19 | 13% |
| Student > Master | 18 | 13% |
| Student > Bachelor | 12 | 8% |
| Student > Doctoral Student | 11 | 8% |
| Other | 25 | 17% |
| Unknown | 34 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 64 | 45% |
| Biochemistry, Genetics and Molecular Biology | 18 | 13% |
| Immunology and Microbiology | 5 | 3% |
| Engineering | 4 | 3% |
| Computer Science | 3 | 2% |
| Other | 11 | 8% |
| Unknown | 38 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2019.
All research outputs
#448,130
of 22,837,982 outputs
Outputs from Scientific Reports
#5,059
of 123,315 outputs
Outputs of similar age
#8,870
of 395,128 outputs
Outputs of similar age from Scientific Reports
#171
of 3,216 outputs
Altmetric has tracked 22,837,982 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 123,315 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,128 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 3,216 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.