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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis
|
|---|---|
| Published in |
Intensive Care Medicine, January 2016
|
| DOI | 10.1007/s00134-015-4188-0 |
| Pubmed ID | |
| Authors |
Mohd H. Abdul-Aziz, Helmi Sulaiman, Mohd-Basri Mat-Nor, Vineya Rai, Kang K. Wong, Mohd S. Hasan, Azrin N. Abd Rahman, Janattul A. Jamal, Steven C. Wallis, Jeffrey Lipman, Christine E. Staatz, Jason A. Roberts |
| Abstract |
This study aims to determine if continuous infusion (CI) is associated with better clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent bolus (IB) dosing in critically ill patients with severe sepsis. This was a two-centre randomised controlled trial of CI versus IB dosing of beta-lactam antibiotics, which enrolled critically ill participants with severe sepsis who were not on renal replacement therapy (RRT). The primary outcome was clinical cure at 14 days after antibiotic cessation. Secondary outcomes were PK/PD target attainment, ICU-free days and ventilator-free days at day 28 post-randomisation, 14- and 30-day survival, and time to white cell count normalisation. A total of 140 participants were enrolled with 70 participants each allocated to CI and IB dosing. CI participants had higher clinical cure rates (56 versus 34 %, p = 0.011) and higher median ventilator-free days (22 versus 14 days, p < 0.043) than IB participants. PK/PD target attainment rates were higher in the CI arm at 100 % fT >MIC than the IB arm on day 1 (97 versus 70 %, p < 0.001) and day 3 (97 versus 68 %, p < 0.001) post-randomisation. There was no difference in 14-day or 30-day survival between the treatment arms. In critically ill patients with severe sepsis not receiving RRT, CI demonstrated higher clinical cure rates and had better PK/PD target attainment compared to IB dosing of beta-lactam antibiotics. Continuous beta-lactam infusion may be mostly advantageous for critically ill patients with high levels of illness severity and not receiving RRT. Malaysian National Medical Research Register ID: NMRR-12-1013-14017. |
X Demographics
The data shown below were collected from the profiles of 81 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 10 | 12% |
| United Kingdom | 7 | 9% |
| Argentina | 6 | 7% |
| Belgium | 4 | 5% |
| Australia | 4 | 5% |
| Mexico | 3 | 4% |
| Brazil | 3 | 4% |
| Colombia | 3 | 4% |
| Japan | 2 | 2% |
| Other | 12 | 15% |
| Unknown | 27 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 54 | 67% |
| Practitioners (doctors, other healthcare professionals) | 17 | 21% |
| Scientists | 8 | 10% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 307 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 305 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 40 | 13% |
| Other | 36 | 12% |
| Student > Ph. D. Student | 29 | 9% |
| Student > Postgraduate | 29 | 9% |
| Student > Master | 27 | 9% |
| Other | 78 | 25% |
| Unknown | 68 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 140 | 46% |
| Pharmacology, Toxicology and Pharmaceutical Science | 45 | 15% |
| Nursing and Health Professions | 8 | 3% |
| Biochemistry, Genetics and Molecular Biology | 6 | 2% |
| Veterinary Science and Veterinary Medicine | 5 | 2% |
| Other | 24 | 8% |
| Unknown | 79 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2017.
All research outputs
#681,686
of 24,995,564 outputs
Outputs from Intensive Care Medicine
#634
of 5,333 outputs
Outputs of similar age
#12,248
of 406,667 outputs
Outputs of similar age from Intensive Care Medicine
#1
of 54 outputs
Altmetric has tracked 24,995,564 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,333 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.5. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,667 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.