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Dissolvable microneedle fabrication using piezoelectric dispensing technology

Overview of attention for article published in International Journal of Pharmaceutics, December 2015
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  • High Attention Score compared to outputs of the same age and source (82nd percentile)

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Title
Dissolvable microneedle fabrication using piezoelectric dispensing technology
Published in
International Journal of Pharmaceutics, December 2015
DOI 10.1016/j.ijpharm.2015.12.052
Pubmed ID
Authors

Evin A. Allen, Conor O’Mahony, Michael Cronin, Thomas O’Mahony, Anne C. Moore, Abina M. Crean

Abstract

Dissolvable microneedle (DMN) patches are novel dosage forms for the percutaneous delivery of vaccines. DMN are routinely fabricated by dispensing liquid formulations into microneedle-shaped moulds. The liquid formulation within the mould is then dried to create dissolvable vaccine-loaded microneedles. The precision of the dispensing process is critical to the control of formulation volume loaded into each dissolvable microneedle structure. The dispensing process employed must maintain vaccine integrity. Wetting of mould surfaces by the dispensed formulation is also an important consideration for the fabrication of sharp-tipped DMN. Sharp-tipped DMN are essential for ease of percutaneous administration. In this paper, we demonstrate the ability of a piezoelectric dispensing system to dispense picolitre formulation volumes into PDMS moulds enabling the fabrication of bilayer DMN. The influence of formulation components (trehalose and polyvinyl alcohol (PVA) content) and piezoelectric actuation parameters (voltage, frequency and backpressure) on drop formation is described. The biological integrity of a seasonal influenza vaccine following dispensing was investigated and maintained voltage settings of 30V but undermined at higher settings, 50 and 80V. The results demonstrate the capability of piezoelectric dispensing technology to precisely fabricate bilayer DMN. They also highlight the importance of identifying formulation and actuation parameters to ensure controlled droplet formulation and vaccine stabilisation.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Unknown 87 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 19%
Researcher 12 14%
Student > Bachelor 9 10%
Student > Master 8 9%
Student > Doctoral Student 4 5%
Other 13 15%
Unknown 25 28%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 21 24%
Engineering 9 10%
Agricultural and Biological Sciences 4 5%
Chemistry 3 3%
Medicine and Dentistry 3 3%
Other 16 18%
Unknown 32 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2022.
All research outputs
#7,942,838
of 25,380,192 outputs
Outputs from International Journal of Pharmaceutics
#2,407
of 8,176 outputs
Outputs of similar age
#114,276
of 395,828 outputs
Outputs of similar age from International Journal of Pharmaceutics
#14
of 80 outputs
Altmetric has tracked 25,380,192 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 8,176 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.