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The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis

Overview of attention for article published in Molecular Neurodegeneration, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet
twitter
2 tweeters

Citations

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14 Dimensions

Readers on

mendeley
16 Mendeley
citeulike
1 CiteULike
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Title
The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis
Published in
Molecular Neurodegeneration, January 2016
DOI 10.1186/s13024-016-0068-5
Pubmed ID
Authors

Yoonhee Kim, Chaeyoung Kim, Sung Min Son, Hyundong Song, Hyun Seok Hong, Sun-ho Han, Inhee Mook-Jung

Abstract

The receptor for advanced glycation end products (RAGE) has been found to interact with amyloid β (Aβ). Although RAGE does not have any kinase motifs in its cytosolic domain, the interaction between RAGE and Aβ triggers multiple cellular signaling involved in Alzheimer's disease (AD). However, the mechanism of signal transduction by RAGE remains still unknown. Therefore, identifying binding proteins of RAGE may provide novel therapeutic targets for AD. In this study, we identified p38-regulated/activated protein kinase (PRAK) as a novel RAGE interacting molecule. To investigate the effect of Aβ on PRAK mediated RAGE signaling pathway, we treated SH-SY5Y cells with monomeric form of Aβ. We demonstrated that Aβ significantly increased the phosphorylation of PRAK as well as the interaction between PRAK and RAGE. We showed that knockdown of PRAK rescued mTORC1 inactivation induced by Aβ treatment and decreased the formation of Aβ-induced autophagosome. We provide evidence that PRAK plays a critical role in AD pathology as a key interactor of RAGE. Thus, our data suggest that PRAK might be a potential therapeutic target of AD involved in RAGE-mediated cell signaling induced by Aβ.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 31%
Student > Bachelor 4 25%
Other 2 13%
Student > Master 2 13%
Student > Ph. D. Student 1 6%
Other 0 0%
Unknown 2 13%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 25%
Agricultural and Biological Sciences 3 19%
Biochemistry, Genetics and Molecular Biology 3 19%
Neuroscience 2 13%
Medicine and Dentistry 1 6%
Other 1 6%
Unknown 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2016.
All research outputs
#691,196
of 7,028,853 outputs
Outputs from Molecular Neurodegeneration
#102
of 349 outputs
Outputs of similar age
#40,668
of 306,195 outputs
Outputs of similar age from Molecular Neurodegeneration
#16
of 25 outputs
Altmetric has tracked 7,028,853 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 349 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,195 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.