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The effect of nucleus basalis magnocellularis deep brain stimulation on memory function in a rat model of dementia

Overview of attention for article published in BMC Neurology, January 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

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1 news outlet

Citations

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14 Dimensions

Readers on

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46 Mendeley
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Title
The effect of nucleus basalis magnocellularis deep brain stimulation on memory function in a rat model of dementia
Published in
BMC Neurology, January 2016
DOI 10.1186/s12883-016-0529-z
Pubmed ID
Authors

Ji Eun Lee, Da Un Jeong, Jihyeon Lee, Won Seok Chang, Jin Woo Chang

Abstract

Deep brain stimulation has recently been considered a potential therapy in improving memory function. It has been shown that a change of neurotransmitters has an effect on memory function. However, much about the exact underlying neural mechanism is not yet completely understood. We therefore examined changes in neurotransmitter systems and spatial memory caused by stimulation of nucleus basalis magnocellularis in a rat model of dementia. We divided rats into four groups: Normal, Lesion, Implantation, and Stimulation. We used 192 IgG-saporin for degeneration of basal forebrain cholinergic neuron related with learning and memory and it was injected into all rats except for the normal group. An electrode was ipsilaterally inserted in the nucleus basalis magnocellularis of all rats of the implantation and stimulation group, and the stimulation group received the electrical stimulation. Features were verified by the Morris water maze, immunochemistry and western blotting. All groups showed similar performances during Morris water maze training. During the probe trial, performance of the lesion and implantation group decreased. However, the stimulation group showed an equivalent performance to the normal group. In the lesion and implantation group, expression of glutamate acid decarboxylase65&67 decreased in the medial prefrontal cortex and expression of glutamate transporters increased in the medial prefrontal cortex and hippocampus. However, expression of the stimulation group showed similar levels as the normal group. The results suggest that nucleus basalis magnocellularis stimulation enhances consolidation and retrieval of visuospatial memory related to changes of glutamate acid decarboxylase65&67 and glutamate transporter.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 20%
Student > Ph. D. Student 8 17%
Student > Master 4 9%
Other 4 9%
Student > Bachelor 4 9%
Other 10 22%
Unknown 7 15%
Readers by discipline Count As %
Neuroscience 12 26%
Medicine and Dentistry 8 17%
Agricultural and Biological Sciences 5 11%
Biochemistry, Genetics and Molecular Biology 3 7%
Psychology 3 7%
Other 5 11%
Unknown 10 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2016.
All research outputs
#934,416
of 6,977,329 outputs
Outputs from BMC Neurology
#187
of 1,118 outputs
Outputs of similar age
#53,684
of 306,138 outputs
Outputs of similar age from BMC Neurology
#9
of 48 outputs
Altmetric has tracked 6,977,329 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,118 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,138 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.