Title |
The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases
|
---|---|
Published in |
Neuroscience Bulletin, January 2016
|
DOI | 10.1007/s12264-015-0004-7 |
Pubmed ID | |
Authors |
Tao Wang, Jian-Qiong Xiong |
Abstract |
The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse, play essential roles in body-pattern formation and neurogenesis during early embryogenesis and perform crucial functions in maintaining stemness and controlling the differentiation of adult neural stem cells in the central nervous system, especially the visual system. Multiple target genes and signaling pathways are regulated by TLX and its homologues in specific tissues during various developmental stages. This review aims to summarize previous studies including many recent updates from different aspects concerning TLX and its homologues in Drosophila and mouse. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 29% |
Researcher | 4 | 14% |
Student > Bachelor | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Professor | 2 | 7% |
Other | 7 | 25% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 25% |
Agricultural and Biological Sciences | 6 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 11% |
Neuroscience | 3 | 11% |
Medicine and Dentistry | 3 | 11% |
Other | 1 | 4% |
Unknown | 5 | 18% |