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Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes

Overview of attention for article published in Brazilian Journal of Anesthesiology (English edition), January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#7 of 244)
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
33 Mendeley
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Title
Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes
Published in
Brazilian Journal of Anesthesiology (English edition), January 2016
DOI 10.1016/j.bjane.2015.01.006
Pubmed ID
Authors

Jun Tian, Yan Li

Abstract

Intra-articular injections of local anesthetics are commonly used to enhance post-operative analgesia following orthopedic surgery as arthroscopic surgeries. Nevertheless, recent reports of severe complications due to the use of intra-articular local anesthetic have raised concerns. The study aims to assess use of vitamin C in reducing adverse effects of the most commonly employed anesthetics - ropivacaine, bupivacaine and lidocaine - on human chondrocytes. The chondrocyte viability following exposure to 0.5% bupivacaine or 0.75% ropivacaine or 1.0% lidocaine and/or vitamin C at doses 125, 250 and 500μM was determined by LIVE/DEAD assay and annexin V staining. Expression levels of caspases 3 and 9 were assessed using antibodies by Western blotting. Flow cytometry was performed to analyze the generation of reactive oxygen species. On exposure to the local anesthetics, chondrotoxicity was found in the order ropivacaine<bupivacaine<lidocaine. Vitamin C effectively improved the reduced chondrocyte viability and decreased the raised apoptosis levels following exposure to anesthesia. At higher doses, vitamin C was found efficient in reducing the generation of reactive oxygen species and as well down-regulate the expressions of caspases 3 and 9. Vitamin C was observed to effectively protect chondrocytes against the toxic insult of local anesthetics ropivacaine, bupivacaine and lidocaine.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 24%
Student > Doctoral Student 4 12%
Researcher 4 12%
Student > Master 3 9%
Student > Ph. D. Student 3 9%
Other 6 18%
Unknown 5 15%
Readers by discipline Count As %
Medicine and Dentistry 11 33%
Nursing and Health Professions 6 18%
Biochemistry, Genetics and Molecular Biology 2 6%
Engineering 2 6%
Social Sciences 1 3%
Other 3 9%
Unknown 8 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2022.
All research outputs
#3,438,597
of 21,035,197 outputs
Outputs from Brazilian Journal of Anesthesiology (English edition)
#7
of 244 outputs
Outputs of similar age
#62,428
of 369,234 outputs
Outputs of similar age from Brazilian Journal of Anesthesiology (English edition)
#1
of 10 outputs
Altmetric has tracked 21,035,197 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 244 research outputs from this source. They receive a mean Attention Score of 2.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,234 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them