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Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health

Overview of attention for article published in Annual Review of Food Science and Technology, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)

Mentioned by

twitter
7 tweeters

Citations

dimensions_citation
99 Dimensions

Readers on

mendeley
206 Mendeley
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Title
Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health
Published in
Annual Review of Food Science and Technology, February 2016
DOI 10.1146/annurev-food-041715-033159
Pubmed ID
Authors

Susan A. Joyce, Cormac G.M. Gahan

Abstract

Bile acids have emerged as important signaling molecules in the host, as they interact either locally or systemically with specific cellular receptors, in particular the farnesoidXreceptor (FXR) and TGR5. These signaling functions influence systemic lipid and cholesterol metabolism, energy metabolism, immune homeostasis, and intestinal electrolyte balance. Through defined enzymatic activities, the gut microbiota can significantly modify the signaling properties of bile acids and therefore can have an impact upon host health. Alterations to the gut microbiota that influence bile acid metabolism are associated with metabolic disease, obesity, diarrhea, inflammatory bowel disease (IBD), Clostridium difficile infection, colorectal cancer, and hepatocellular carcinoma. Here, we examine the regulation of this gut-microbiota-liver axis in the context of bile acid metabolism and indicate how this pathway represents an important target for the development of new nutraceutical (diet and/or probiotics) and targeted pharmaceutical interventions. Expected final online publication date for the Annual Review of Food Science and Technology Volume 7 is February 28, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 206 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Unknown 205 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 20%
Researcher 32 16%
Student > Master 25 12%
Student > Bachelor 15 7%
Student > Doctoral Student 14 7%
Other 40 19%
Unknown 39 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 20%
Biochemistry, Genetics and Molecular Biology 36 17%
Medicine and Dentistry 30 15%
Immunology and Microbiology 19 9%
Nursing and Health Professions 14 7%
Other 19 9%
Unknown 46 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2017.
All research outputs
#2,228,068
of 9,243,111 outputs
Outputs from Annual Review of Food Science and Technology
#31
of 82 outputs
Outputs of similar age
#90,419
of 336,766 outputs
Outputs of similar age from Annual Review of Food Science and Technology
#13
of 16 outputs
Altmetric has tracked 9,243,111 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,766 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.