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Joint sparing treatments in early ankle osteoarthritis: current procedures and future perspectives

Overview of attention for article published in Journal of Experimental Orthopaedics, January 2016
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Title
Joint sparing treatments in early ankle osteoarthritis: current procedures and future perspectives
Published in
Journal of Experimental Orthopaedics, January 2016
DOI 10.1186/s40634-016-0038-4
Pubmed ID
Authors

Francesco Castagnini, Camilla Pellegrini, Luca Perazzo, Francesca Vannini, Roberto Buda

Abstract

Ankle osteoarthritis (AOA) is a severe pathology, mostly affecting a post-traumatic young population. Arthroscopic debridement, arthrodiastasis, osteotomy are the current joint sparing procedures, but, in the available studies, controversial results were achieved, with better outcomes in case of limited degeneration. Only osteotomy in case of malalignment is universally accepted as a joint sparing procedure in case of partial AOA. Recently, the biological mechanism of osteoarthritis has been intensively studied: it is a whole joint pathology, affecting cartilage, bone and synovial membrane. In particular, the first stage is characterized by a reversible catabolic activity with a state of chondropenia. Thus, biological procedures for early AOA were proposed in order to delay or to avoid end stage procedures. Mesenchymal stem cells (MSCs) may be a good solution to prevent or reverse degeneration, due to their immunomodulatory features (able to control the catabolic joint environment) and their regenerative osteochondral capabilities (able to treat the chondral defects). In fact, MSCs may regulate the cytokine cascade and the metalloproteinases release, restoring the osteochondral tissue as well. After interesting reports of mesenchymal stem cells seeded on scaffold and applied to cartilage defects in non-degenerated joints, bone marrow derived cells transplantation appears to be a promising technique in order to control the degenerative pathway and restore the osteochondral defects.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 32%
Student > Ph. D. Student 4 18%
Student > Postgraduate 3 14%
Researcher 3 14%
Student > Doctoral Student 1 5%
Other 2 9%
Unknown 2 9%
Readers by discipline Count As %
Medicine and Dentistry 13 59%
Engineering 3 14%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 1 5%
Unknown 2 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2016.
All research outputs
#5,222,032
of 6,988,129 outputs
Outputs from Journal of Experimental Orthopaedics
#13
of 20 outputs
Outputs of similar age
#215,707
of 314,468 outputs
Outputs of similar age from Journal of Experimental Orthopaedics
#4
of 5 outputs
Altmetric has tracked 6,988,129 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20 research outputs from this source. They receive a mean Attention Score of 2.4. This one scored the same or higher as 7 of them.
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