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Static compression regulates OPG expression in periodontal ligament cells via the CAMK II pathway

Overview of attention for article published in Journal of Applied Oral Science, December 2015
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Title
Static compression regulates OPG expression in periodontal ligament cells via the CAMK II pathway
Published in
Journal of Applied Oral Science, December 2015
DOI 10.1590/1678-775720150156
Pubmed ID
Authors

Jianru, YI, MeiLe, LI, YANG, Yan, ZHENG, Wei, Yu, LI, ZHAO, Zhihe, Jianru, YI, MeiLe, LI, YANG, Yan, ZHENG, Wei, Yu, LI, ZHAO, Zhihe

Abstract

Objective This study aimed to investigate the potential role of CAMK II pathway in the compression-regulated OPG expression in periodontal ligament cells (PDLCs). Material and Methods The PDL tissue model was developed by 3-D culturing human PDLCs in a thin sheet of poly lactic-co-glycolic acid (PLGA) scaffolds, which was subjected to static compression of 25 g/cm2 for 3, 6 and 12 h, with or without treatment of KN-93. After that, the expression of OPG, RANKL and NFATC2 was investigated through real-time PCR and western blot analysis. Results After static compression, the NFATC2 and RANKL expression was significantly up-regulated, while partially suppressed by KN-93 for 6 and 12 h respectively. The OPG expression was significantly down-regulated by compression in 3 h, started to elevate in 6 h, and significantly up-regulated in 12 h. The up-regulation after 12 h was significantly suppressed by KN-93. Conclusions Long-term static compression increases OPG expression in PDLCs, at least partially, via the CAMK II pathway.

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Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Student > Bachelor 4 19%
Student > Postgraduate 2 10%
Professor 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 7 33%
Readers by discipline Count As %
Medicine and Dentistry 7 33%
Biochemistry, Genetics and Molecular Biology 2 10%
Psychology 1 5%
Agricultural and Biological Sciences 1 5%
Social Sciences 1 5%
Other 2 10%
Unknown 7 33%