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Effect of collagen sponge and fibrin glue on bone repair

Overview of attention for article published in Journal of Applied Oral Science, December 2015
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Title
Effect of collagen sponge and fibrin glue on bone repair
Published in
Journal of Applied Oral Science, December 2015
DOI 10.1590/1678-775720150374
Pubmed ID
Authors

SANTOS, Thiago de Santana, ABUNA, Rodrigo Paolo Flores, ALMEIDA, Adriana Luisa Gonçalves de, BELOTI, Marcio Mateus, ROSA, Adalberto Luiz, SANTOS, Thiago de Santana, ABUNA, Rodrigo Paolo Flores, ALMEIDA, Adriana Luisa Gonçalves de, BELOTI, Marcio Mateus, ROSA, Adalberto Luiz

Abstract

The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. Objective In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. Material and Methods Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). Results Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. Conclusion Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 16%
Student > Ph. D. Student 5 10%
Researcher 5 10%
Student > Doctoral Student 4 8%
Student > Bachelor 3 6%
Other 7 14%
Unknown 18 36%
Readers by discipline Count As %
Medicine and Dentistry 13 26%
Agricultural and Biological Sciences 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Materials Science 2 4%
Engineering 2 4%
Other 2 4%
Unknown 22 44%