Title |
Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice
|
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Published in |
BMC Pharmacology, December 2002
|
DOI | 10.1186/1471-2210-2-21 |
Pubmed ID | |
Authors |
Hossein Hosseinzadeh, Gholam_Reza Karimi, Maryam Ameri |
Abstract |
As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveolens in mice. Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p., (1.5, 6.16) and 6.98 g/kg, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts. The results suggest that A. graveolens seed extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 13% |
Student > Ph. D. Student | 6 | 11% |
Student > Doctoral Student | 5 | 9% |
Student > Master | 5 | 9% |
Other | 3 | 6% |
Other | 8 | 15% |
Unknown | 19 | 36% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 6 | 11% |
Chemistry | 3 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Medicine and Dentistry | 2 | 4% |
Other | 6 | 11% |
Unknown | 21 | 40% |