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Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque

Overview of attention for article published in Stem Cells, February 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

twitter
8 tweeters
facebook
1 Facebook page

Citations

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22 Dimensions

Readers on

mendeley
27 Mendeley
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Title
Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque
Published in
Stem Cells, February 2016
DOI 10.1002/stem.2315
Pubmed ID
Authors

Leszczynska, Aleksandra, O'Doherty, Aideen, Farrell, Eric, Pindjakova, Jana, O'Brien, Fergal J., O'Brien, Timothy, Barry, Frank, Murphy, J. Mary, Murphy, Mary, O'Brien, Fergal J, Murphy, J Mary

Abstract

The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque environment to this process. VSCs and MSCs isolated from atherosclerotic ApoE(-/-) mice showed significantly more in vitro osteogenesis and chondrogenesis than cells generated from control C57BL/6 mice. To assess their ability to form bone in vivo, cells were primed chondrogenically or cultured in control medium on collagen glycosaminoglycan scaffolds in vitro prior to subcutaneous implantation in ApoE(-/-) and C57BL/6 mice using a crossover study design. Atherosclerotic ApoE(-/-) MSCs and VSCs formed bone when implanted in C57BL/6 mice. In ApoE(-/-) mice, these cells generated more mature bone than C57BL/6 cells. The atherosclerotic in vivo environment alone promoted bone formation by implanted C57BL/6 cells. Un-primed C57BL/6 VSCs were unable to form bone in either mouse strain. Treatment of ApoE(-/-) VSC chondrogenic cultures with interleukin (IL)-6 resulted in significantly increased glycosaminoglycan deposition and expression of characteristic chondrogenic genes at 21 days. In conclusion, resident vascular cells from atherosclerotic environment respond to the inflammatory milieu and undergo calcification. IL-6 may have a role in aberrant differentiation of VSCs contributing to vascular calcification in atherosclerosis. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Netherlands 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 30%
Student > Ph. D. Student 5 19%
Student > Master 4 15%
Student > Doctoral Student 2 7%
Lecturer > Senior Lecturer 1 4%
Other 4 15%
Unknown 3 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 22%
Biochemistry, Genetics and Molecular Biology 5 19%
Medicine and Dentistry 5 19%
Engineering 4 15%
Psychology 1 4%
Other 0 0%
Unknown 6 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2016.
All research outputs
#4,001,071
of 15,392,549 outputs
Outputs from Stem Cells
#1,392
of 3,498 outputs
Outputs of similar age
#84,696
of 343,806 outputs
Outputs of similar age from Stem Cells
#38
of 100 outputs
Altmetric has tracked 15,392,549 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 3,498 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,806 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.