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General Anesthetics Inhibit Erythropoietin Induction under Hypoxic Conditions in the Mouse Brain

Overview of attention for article published in PLOS ONE, December 2011
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Title
General Anesthetics Inhibit Erythropoietin Induction under Hypoxic Conditions in the Mouse Brain
Published in
PLOS ONE, December 2011
DOI 10.1371/journal.pone.0029378
Pubmed ID
Authors

Tomoharu Tanaka, Shinichi Kai, Tomohiro Koyama, Hiroki Daijo, Takehiko Adachi, Kazuhiko Fukuda, Kiichi Hirota

Abstract

Erythropoietin (EPO), originally identified as a hematopoietic growth factor produced in the kidney and fetal liver, is also endogenously expressed in the central nervous system (CNS). EPO in the CNS, mainly produced in astrocytes, is induced under hypoxic conditions in a hypoxia-inducible factor (HIF)-dependent manner and plays a dominant role in neuroprotection and neurogenesis. We investigated the effect of general anesthetics on EPO expression in the mouse brain and primary cultured astrocytes.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
United States 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 16%
Researcher 5 16%
Professor > Associate Professor 5 16%
Student > Bachelor 4 13%
Student > Doctoral Student 3 9%
Other 6 19%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 10 31%
Agricultural and Biological Sciences 6 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Veterinary Science and Veterinary Medicine 2 6%
Other 5 16%
Unknown 5 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2012.
All research outputs
#18,303,139
of 22,660,862 outputs
Outputs from PLOS ONE
#153,700
of 193,497 outputs
Outputs of similar age
#195,770
of 243,649 outputs
Outputs of similar age from PLOS ONE
#2,192
of 2,948 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,497 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,649 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,948 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.