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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers
|
|---|---|
| Published in |
Cancer Cell, February 2016
|
| DOI | 10.1016/j.ccell.2016.01.001 |
| Pubmed ID | |
| Authors |
Mélodie Grandin, Markus Meier, Jean Guy Delcros, Denise Nikodemus, Raphael Reuten, Trushar R. Patel, David Goldschneider, George Orriss, Natalie Krahn, Amina Boussouar, Riad Abes, Yann Dean, David Neves, Agnes Bernet, Stephane Depil, Fiona Schneiders, Kate Poole, Robert Dante, Manuel Koch, Patrick Mehlen, Jörg Stetefeld |
| Abstract |
Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 40% |
| United States | 1 | 20% |
| Brazil | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 18% |
| Researcher | 19 | 16% |
| Student > Bachelor | 13 | 11% |
| Other | 10 | 8% |
| Student > Master | 7 | 6% |
| Other | 21 | 17% |
| Unknown | 29 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 23% |
| Agricultural and Biological Sciences | 19 | 16% |
| Medicine and Dentistry | 11 | 9% |
| Chemistry | 7 | 6% |
| Neuroscience | 4 | 3% |
| Other | 18 | 15% |
| Unknown | 34 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2023.
All research outputs
#4,166,588
of 25,371,288 outputs
Outputs from Cancer Cell
#1,924
of 3,149 outputs
Outputs of similar age
#67,691
of 406,420 outputs
Outputs of similar age from Cancer Cell
#29
of 44 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,420 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.